Grant: Operating Grant
Ottawa Hospital Research Institute
$734,540.00
Dystonin - a cytoskeletal linker protein critical for neuronal function
FY 2012-13
Summary
Defects in cytoskeletal proteins have a primary role in many neurodegenerative diseases. In working towards therapies for
these diseases, it is important to understand the basic context in which the conditions occur. Implicit in this is an
understanding of the basic architectural makeup of cells and the molecular determinants that are required in establishing a
normal framework. Our work on dystonin cytoskeletal proteins show that they are fundamental in facilitating communication
from the nucleus to the plasma membrane by ensuring the stability of the cellular scaffold. The work proposed will shed light
on the role of this protein in intracellular trafficking and organelle organization. Since cytoskeletal defects are central features
of many neurodegenerative disorders, elucidation of the exact role of dystonin in neurons should not only enhance our
understanding of the versatile nature of these large modular proteins, but should help provide fundamental insight into the
aetiology of these disorders.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
266669
Name
Kothary Rashmi K
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Cell Biology & Mechanisms of Disease
Projecttitle
Dystonin - a cytoskeletal linker protein critical for neuronal function
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$734,540
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Autophagy; Cytoskeletal Linker Proteins; Established And Primary Cell Culture Models; Intracellular Trafficking; Microtubule Dynamics; Mouse Models; Neurodegenerative Diseases; Neuronal Integrity; Transgenic Mice
Abstract
Defects in cytoskeletal proteins have a primary role in many neurodegenerative diseases. In working towards therapies for
these diseases, it is important to understand the basic context in which the conditions occur. Implicit in this is an
understanding of the basic architectural makeup of cells and the molecular determinants that are required in establishing a
normal framework. Our work on dystonin cytoskeletal proteins show that they are fundamental in facilitating communication
from the nucleus to the plasma membrane by ensuring the stability of the cellular scaffold. The work proposed will shed light
on the role of this protein in intracellular trafficking and organelle organization. Since cytoskeletal defects are central features
of many neurodegenerative disorders, elucidation of the exact role of dystonin in neurons should not only enhance our
understanding of the versatile nature of these large modular proteins, but should help provide fundamental insight into the
aetiology of these disorders.
Competitiondate
201209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Kothary, Rashmi K
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $734,540~ $0~
