Grant: Project Grant
University of British Columbia
$830,025.00
Phosphorylation of Cardiac Ryanodine Receptors
FY 2016-17
Summary
Our hearts require calcium ions to contract. These calcium ions get released from a special store through a gate. The gate is formed by a protein, known as the Ryanodine Receptor. It is absolutely crucial that the gate opens and closes at appropriate time points. Any deviation can lead to excessive calcium, with a resulting cardiac arrhythmia. In some cases, the gate dysfunctions because of a genetic mutation. Such mutations lead to stress-induced arrhythmias and the patients are at risk for sudden cardiac death. In other cases, aging can result in small modifications of the gate, causing it to open too easily. This is a situation often occurring in heart failure, a conditions affecting ~600,000 Canadians. The resulting arrhythmia can often be fatal. This project aims to study how the gate dysfunctions due to the small modifications.
Department
Program
Project Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
354570
Name
Van Petegem Filip
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
Phosphorylation of Cardiac Ryanodine Receptors
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$830,025
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Biochemistry; Calcium Signaling; Cardiac Arrhythmia; Heart Failure; Ion Channel; Phosphorylation; Ryanodine Receptor; X-Ray Crystallography
Abstract
Our hearts require calcium ions to contract. These calcium ions get released from a special store through a gate. The gate is formed by a protein, known as the Ryanodine Receptor. It is absolutely crucial that the gate opens and closes at appropriate time points. Any deviation can lead to excessive calcium, with a resulting cardiac arrhythmia. In some cases, the gate dysfunctions because of a genetic mutation. Such mutations lead to stress-induced arrhythmias and the patients are at risk for sudden cardiac death. In other cases, aging can result in small modifications of the gate, causing it to open too easily. This is a situation often occurring in heart failure, a conditions affecting ~600,000 Canadians. The resulting arrhythmia can often be fatal. This project aims to study how the gate dysfunctions due to the small modifications.
Competitiondate
201610
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Van Petegem, Filip
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $830,025~ $0~
