Grant: Operating Grant
Institut de recherches cliniques de Montréal
$840,320.00
Role and signaling mechanism of EAT-2, an adaptor involved in anti-tumor immunity
FY 2009-10
Summary
EAT-2 is a small molecule named "adaptor" that is expressed in cells of the immune system. A closely related protein, SAP, is mutated in boys suffering from X-linked lymphoproliferative (XLP) disease. Our recent work shows that the EAT-2 protein plays a critical role in the normal immune response, in particular against cancer cells or cells infected by viruses. In keeping with this, we found that mice that were engineered to lack the EAT-2 molecule have an altered capacity to eliminate cancer cells.
This grant proposal is aimed at understanding better the molecular mechanism of action and role of EAT-2 in immune cells, especially in anti-cancer responses. We hope that this work will not only improve our comprehension of the processes controlling the normal immune response, but will also help identify new ways of treating human illnesses such as cancer and viral infections.
Department
Program
Operating Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
199519
Name
Veillette André
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cell Physiology
Projecttitle
Role and signaling mechanism of EAT-2, an adaptor involved in anti-tumor immunity
Programtype2
Operating Grants
Orgnameinp2
Institut de recherches cliniques de Montréal
Cihramount2
$840,320
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Adaptors; Immune Cells; Nk Cells; Receptors; Signaling
Abstract
EAT-2 is a small molecule named "adaptor" that is expressed in cells of the immune system. A closely related protein, SAP, is mutated in boys suffering from X-linked lymphoproliferative (XLP) disease. Our recent work shows that the EAT-2 protein plays a critical role in the normal immune response, in particular against cancer cells or cells infected by viruses. In keeping with this, we found that mice that were engineered to lack the EAT-2 molecule have an altered capacity to eliminate cancer cells.
This grant proposal is aimed at understanding better the molecular mechanism of action and role of EAT-2 in immune cells, especially in anti-cancer responses. We hope that this work will not only improve our comprehension of the processes controlling the normal immune response, but will also help identify new ways of treating human illnesses such as cancer and viral infections.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Veillette, André
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $840,320~ $0~
