Grant: Operating Grant - Priority Announcement: Breast Cancer
University of Guelph
$483,311.00
n-3 polyunsaturated fatty acids influence mammary gland development and carcinogenesis
FY 2010-11
Summary
Breast cancer is a leading cause of cancer death in Canadian women. The origins of this disease in women may be linked to the profound changes that occur during pubertal breast development early in life. Currently, our understanding of the mechanisms and factors that co-ordinately influence mammary gland development and risk for cancer in adulthood is poorly understood. We are interested in n-3 polyunsaturated fatty acids (PUFA), derived from fish oils which may have potential therapeutic effects for the prevention of breast cancer. In this proposal, we will investigate how n-3 PUFA influences mammary gland development and the long term effects on developing cancer in adulthood. It is anticipated that the proposed research will enhance our fundamental knowledge of how dietary n-3 PUFA may have utility in the prevention of breast cancer.
Department
Program
Operating Grant - Priority Announcement: Breast Cancer
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
231252
Name
Ma David W
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Nutrition, Food & Health
Projecttitle
n-3 polyunsaturated fatty acids influence mammary gland development and carcinogenesis
Programtype2
Operating Grants
Orgnameinp2
University of Guelph
Cihramount2
$483,311
Cihrequipment2
$0
Programname2
Operating Grant - Priority Announcement: Breast Cancer
Keyworddelim
Breast Cancer; Cancer Prevention; Caveolae/Lipid Rafts; Caveolin-1; Cell Signalling; Diet And Cancer; Marine Oils; N-3 Polyunsaturated Fatty Acids; Nutrition; Puberty
Abstract
Breast cancer is a leading cause of cancer death in Canadian women. The origins of this disease in women may be linked to the profound changes that occur during pubertal breast development early in life. Currently, our understanding of the mechanisms and factors that co-ordinately influence mammary gland development and risk for cancer in adulthood is poorly understood. We are interested in n-3 polyunsaturated fatty acids (PUFA), derived from fish oils which may have potential therapeutic effects for the prevention of breast cancer. In this proposal, we will investigate how n-3 PUFA influences mammary gland development and the long term effects on developing cancer in adulthood. It is anticipated that the proposed research will enhance our fundamental knowledge of how dietary n-3 PUFA may have utility in the prevention of breast cancer.
Competitiondate
201103
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Ma, David W
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $483,311~ $0~
