Grant: CIHR Fellowship
Direct Payment
$150,000.00
A systems approach to the origin of glycosomes
FY 2014-15
Summary
Leishmaniasis, Chagas disease and African sleeping sickness are three neglected tropical diseases caused by a group of related protozoan parasites known as the trypanosomatids. These parasites rely on a cellular compartment termed a glycosome for energy production. However, how glycosomes are formed is not known despite this being an outstanding question of medical, biological and evolutionary importance. This proposal outlines a strategy for determining how glycosomes are formed and for identifying proteins involved in this process. New proteins involved in forming glycosomes and that are essential for parasite survival will be targeted for drug development.
Department
Program
CIHR Fellowship
Recipient
Location
Washington, United States of America
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
319278
Name
Mast Fred D
Region
Washington
Country
United States of America
Orgtype
Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
A systems approach to the origin of glycosomes
Programtype2
Fellowship Programs
Orgnameinp2
Direct Payment
Cihramount2
$150,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Cryolysis; Drug Discovery; Evolutionary Cell Biology; Glycosome; Organelle Biogenesis; Protein Trafficking; Proteomics; Systems Cell Biology; Trypanosomatids; Trypanosomiasis
Abstract
Leishmaniasis, Chagas disease and African sleeping sickness are three neglected tropical diseases caused by a group of related protozoan parasites known as the trypanosomatids. These parasites rely on a cellular compartment termed a glycosome for energy production. However, how glycosomes are formed is not known despite this being an outstanding question of medical, biological and evolutionary importance. This proposal outlines a strategy for determining how glycosomes are formed and for identifying proteins involved in this process. New proteins involved in forming glycosomes and that are essential for parasite survival will be targeted for drug development.
Competitiondate
201411
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Mast, Fred D
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $150,000~ $0~
