Grant: Project Grant
Research Institute of the McGill University Health Centre
$795,600.00
Prophylactic EUS-guided gastroenterostomy in advanced periampullary cancers: A multicenter randomized controlled trial (INTERCEPT study)
FY 2023-24
Summary
In cases of certain cancers near the small intestine's opening, a common problem called Malignant Gastric Outlet Obstruction (MGOO) can occur. This leads to serious health issues, malnutrition, and even stopping chemotherapy. A surgical procedure called prophylactic surgical gastrojejunostomy has been proven to help prevent MGOO and is used when cancer can't be removed during surgery. However, for most patients, MGOO is only treated when there are clear signs of blockage. A new approach using a special kind of endoscopy called EUS-guided gastroenterostomy (EUS-GE) could potentially prevent MGOO before it becomes a problem. Our study aims to find out if doing this procedure early (ProEUS-GE) can stop MGOO from happening, reducing health issues and interruptions in chemotherapy. ProEUSGE could be better than the current "wait and see" approach. We'll compare ProEUS-GE with the usual care in a study involving multiple medical centers. Our main goal is to see if ProEUS-GE lowers the rate of MGOO, and we'll also look at safety and nutrition outcomes. This study could change how we manage periampullary cancers and significantly improve patient care.
Department
Program
Project Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
501682
Name
Chen Yen-I
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Clinical
Prcname2
Clinical Investigation - C: Digestive, Endocrine and Excretory Systems
Projecttitle
Prophylactic EUS-guided gastroenterostomy in advanced periampullary cancers: A multicenter randomized controlled trial (INTERCEPT study)
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$795,600
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Endoscopic Bypass; Endoscopic Stent Insertion; Endoscopic Ultrasound Guided Gastroenterostomy; Gastroenterology; Malignant Gastric Outlet Obstruction; Pancreatic Cancer; Randomized Controlled Trial; Therapeutic Endoscopic Ultrasound; Therapeutic Gastrointestinal Endoscopy
Abstract
In cases of certain cancers near the small intestine's opening, a common problem called Malignant Gastric Outlet Obstruction (MGOO) can occur. This leads to serious health issues, malnutrition, and even stopping chemotherapy. A surgical procedure called prophylactic surgical gastrojejunostomy has been proven to help prevent MGOO and is used when cancer can't be removed during surgery. However, for most patients, MGOO is only treated when there are clear signs of blockage. A new approach using a special kind of endoscopy called EUS-guided gastroenterostomy (EUS-GE) could potentially prevent MGOO before it becomes a problem. Our study aims to find out if doing this procedure early (ProEUS-GE) can stop MGOO from happening, reducing health issues and interruptions in chemotherapy. ProEUSGE could be better than the current "wait and see" approach. We'll compare ProEUS-GE with the usual care in a study involving multiple medical centers. Our main goal is to see if ProEUS-GE lowers the rate of MGOO, and we'll also look at safety and nutrition outcomes. This study could change how we manage periampullary cancers and significantly improve patient care.
Competitiondate
202403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Chen, Yen-I; Barkun, Jeffrey Stewart T; Causada Calo, Natalia S
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $795,600~ $0~
