Grant: Operating Grant
University of Calgary
$715,686.00
NSAID-Enteropathy: From Pathogenesis to Prevention
FY 2012-13
Summary
Most of the drugs most commonly taken for pain and inflammation, including for arthritis, frequently cause significant damage and bleeding in the intestine. This is a very serious effect of these drugs, that often goes undetected, and for which there are no effective treatments. Drugs taken to protect the stomach from these drugs actually worsen the damage and bleeding caused in the intestine. Our research project will identify the main mechanisms through which this damage and bleeding is produced, and we will develop a method for preventing this life-threatening side effect of very commonly used medications.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
278227
Name
Wallace John L
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Hematology, Digestive Disease & Kidney
Projecttitle
NSAID-Enteropathy: From Pathogenesis to Prevention
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$715,686
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Drug Development; Hemorrhage; Hydrogen Sulfide; Inflammation; Mucosal Injury; Prostaglandins; Ulcer
Abstract
Most of the drugs most commonly taken for pain and inflammation, including for arthritis, frequently cause significant damage and bleeding in the intestine. This is a very serious effect of these drugs, that often goes undetected, and for which there are no effective treatments. Drugs taken to protect the stomach from these drugs actually worsen the damage and bleeding caused in the intestine. Our research project will identify the main mechanisms through which this damage and bleeding is produced, and we will develop a method for preventing this life-threatening side effect of very commonly used medications.
Competitiondate
201303
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Wallace, John L
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $715,686~ $0~
