Grant: Canada Research Chairs
University of Manitoba
$120,000.00
Cell Stress and Inflammation
FY 2023-24
Summary
To function properly proteins must be folded into the correct shape. Sometimes protein folding does not occur correctly and misfolded proteins accumulate. If prolonged or extensive, this leads to cell death. Stress responses help lower the level of misfolded proteins. Recent evidence suggests stress responses can also alter cell-to-cell communication but we do not understand how. This research program asks how stressed cells communicate with and influence their neighbouring cells. This knowledge will greatly increase our understanding of cellular stress responses in the context of the body as a whole, and not as isolated events occurring in single, stressed cells.
Program
Canada Research Chairs
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
CRC-2018-00305
Name nom
Logue, Susan
Department département
Human Anatomy and Cell Science - University of Manitoba
Organization id
19
Institution établissement
University of Manitoba
Province en
Manitoba
Province fr
Manitoba
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2023
Competition year année de concours
2018
Award amount
120000
Program id
CRC
Program name en
Canada Research Chairs
Program name fr
Chaires de recherche du Canada
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
9998
Committee name en
Canada Research Chair Selection Committee
Committee name fr
Comité de sélection des Chaires de recherche du Canada
Area of application code
9999
Area of application group en
Not available
Area of application group fr
Non disponible
Area of application en
Not available
Area of application fr
Non disponible
Research subject code
10000
Research subject group en
The field of research available
Research subject group fr
The field of research available
Research subject en
Le domaine de recherche disponible
Research subject fr
Le domaine de recherche disponible
Field of research list codes
RDF10601;RDF10602
Field of research list names en
Biochemistry;Cell biology
Field of research list names fr
Biochimie;Biologie cellulaire
Application title
Cell Stress and Inflammation
Keyword
Cell communication
cell stress
endoplasmic reticulum
unfolded protein response
Application summary
To function properly proteins must be folded into the correct shape. Sometimes protein folding does not occur correctly and misfolded proteins accumulate. If prolonged or extensive, this leads to cell death. Stress responses help lower the level of misfolded proteins. Recent evidence suggests stress responses can also alter cell-to-cell communication but we do not understand how. This research program asks how stressed cells communicate with and influence their neighbouring cells. This knowledge will greatly increase our understanding of cellular stress responses in the context of the body as a whole, and not as isolated events occurring in single, stressed cells.
