Grant: Project Grant
Université Laval
$914,175.00
Function and neuroprotective potential of new target genes against Parkinson's disease
FY 2020-21
Summary
Parkinson disease (PD) is an important neurodegenerative disorder affecting more than 55,000 Canadians. Yet, no cure exists and current treatments only alleviate part of the motor symptoms associated with the disease. The main pathological feature of PD is the progressive degeneration of midbrain dopaminergic neurons. It is thus crucial to develop new treatments that could slowdown and eventually stop the degeneration of these neurons. We recently identified new target genes that could potentially protect dopaminergic neurons against neurodegeneration. Thus, we propose to elucidate the function of these genes and test their neuroprotective potential in a preclinical models of PD.
Department
Program
Project Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
433760
Name
Lévesque Martin
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Molecular & Cellular Neurosciences - B
Projecttitle
Function and neuroprotective potential of new target genes against Parkinson's disease
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$914,175
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Alpha-Synuclein; Animal Model; Crispr/Cas9; Dopamine Neurons; In Vitro Model; Mice; Neurodegeneration; Neuroprotection; Parkinson'S Disease; Viral Vector
Abstract
Parkinson disease (PD) is an important neurodegenerative disorder affecting more than 55,000 Canadians. Yet, no cure exists and current treatments only alleviate part of the motor symptoms associated with the disease. The main pathological feature of PD is the progressive degeneration of midbrain dopaminergic neurons. It is thus crucial to develop new treatments that could slowdown and eventually stop the degeneration of these neurons. We recently identified new target genes that could potentially protect dopaminergic neurons against neurodegeneration. Thus, we propose to elucidate the function of these genes and test their neuroprotective potential in a preclinical models of PD.
Competitiondate
202010
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Lévesque, Martin
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $914,175~ $0~
