Grant: Operating Grant
York University (Toronto, Ontario)
$376,002.00
Regulation of MEF2 activity in cardiac and skeletal muscle
FY 2009-10
Summary
Control of gene expression is the fundamental process underlying development, normal healthy function and pathology of the heart and skeletal muscle. In this work we are studying the proteins that exert control over how, when and why specific genes are turned on or off in the heart and skeletal muscle. This work will inform us regarding key events that maintain these tissues in a healthy state and also what goes wrong at the genetic level in disease states leading to heart failure.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
190034
Name
McDermott John C
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Genetics
Theme2
Biomedical
Prcname2
Cardiovascular System - A: Cells and Tissues
Projecttitle
Regulation of MEF2 activity in cardiac and skeletal muscle
Programtype2
Operating Grants
Orgnameinp2
York University (Toronto, Ontario)
Cihramount2
$376,002
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cardiac Hypertrophy; Cardiac Muscle; Gene Expression; Mef2; Proteomics; Transcription
Abstract
Control of gene expression is the fundamental process underlying development, normal healthy function and pathology of the heart and skeletal muscle. In this work we are studying the proteins that exert control over how, when and why specific genes are turned on or off in the heart and skeletal muscle. This work will inform us regarding key events that maintain these tissues in a healthy state and also what goes wrong at the genetic level in disease states leading to heart failure.
Competitiondate
200909
Approvedterm2
3 yrs 0 mth
Pinamesdelim
McDermott, John C
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $376,002~ $0~
