Grant: Operating Grant
McGill University
$497,573.00
Acute bacterial infection promotes cancer metastasis through toll like receptor signal transduction
FY 2010-11
Summary
Lung cancer is the leading cause of cancer related death in the world. Surgery is the cornerstone of curative treatment but is associated with a high rate of infectious complications including pneumonia. There is emerging clinical data to suggest that complications after surgery may increase cancer recurrence. This present study investigates the relationship between bacterial infection and cancer progression, with a particular focus on specialized bacteria recognition proteins, the Toll Like Receptors. Results from this proposal will identify Toll Like Receptors as a potential target in the treatment and prevention of cancer progression.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
224180
Name
Ferri Lorenzo
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Progression & Therapeutics 2
Projecttitle
Acute bacterial infection promotes cancer metastasis through toll like receptor signal transduction
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$497,573
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Bacteria; Intravital Microscopy; Lung Cancer; Metastasis; Mice; Pneumonia; Signal Transduction; Toll Like Receptor
Abstract
Lung cancer is the leading cause of cancer related death in the world. Surgery is the cornerstone of curative treatment but is associated with a high rate of infectious complications including pneumonia. There is emerging clinical data to suggest that complications after surgery may increase cancer recurrence. This present study investigates the relationship between bacterial infection and cancer progression, with a particular focus on specialized bacteria recognition proteins, the Toll Like Receptors. Results from this proposal will identify Toll Like Receptors as a potential target in the treatment and prevention of cancer progression.
Competitiondate
201103
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Ferri, Lorenzo
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $497,573~ $0~
