Grant: Operating Grant: Health Systems Research on H1N1
University of British Columbia
$94,155.00
Exacerbation of H1N1 Influenza infection with inhaled therapeutics in primary epithelial cells and ex vivo tissue from asthma patients: clarification of primary treatment strategies during pandemic influenza seasons
FY 2009-10
Summary
People with asthma were most likely to be hospitalised due to Pandemic H1N1 Influenza during the 2009-2010 winter season. Diseases like asthma cause a person to have breathing difficulties because the breathing tubes (also called the airways) become blocked with mucus and inflammatory debris. Why people develop asthma is unknown but research from our lab shows that cells that line the breathing tubes in people with asthma are abnormal and may be more susceptible to infection. Also, asthma is often treated with anti-inflammatory drugs that contain steroids, which help to clear up the airways. In this study, we will perform experiments to see whether or not the H1N1 virus is more likely to enter into the breathing tubes of patients with asthma than those of people without asthma. As well, we will see whether or not the use of steroid puffers makes the breathing tubes more vulnerable to H1N1 infection.
Department
Program
Operating Grant: Health Systems Research on H1N1
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
198465
Name
Knight Darryl A
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Operating Grant: Health Systems Research on H1N1
Projecttitle
Exacerbation of H1N1 Influenza infection with inhaled therapeutics in primary epithelial cells and ex vivo tissue from asthma patients: clarification of primary treatment strategies during pandemic influenza seasons
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$94,155
Cihrequipment2
$0
Programname2
Operating Grant: Health Systems Research on H1N1
Keyworddelim
Asthma; Drug Interactions; H1n1 Influenza; P38; Signalling; Steroids
Abstract
People with asthma were most likely to be hospitalised due to Pandemic H1N1 Influenza during the 2009-2010 winter season. Diseases like asthma cause a person to have breathing difficulties because the breathing tubes (also called the airways) become blocked with mucus and inflammatory debris. Why people develop asthma is unknown but research from our lab shows that cells that line the breathing tubes in people with asthma are abnormal and may be more susceptible to infection. Also, asthma is often treated with anti-inflammatory drugs that contain steroids, which help to clear up the airways. In this study, we will perform experiments to see whether or not the H1N1 virus is more likely to enter into the breathing tubes of patients with asthma than those of people without asthma. As well, we will see whether or not the use of steroid puffers makes the breathing tubes more vulnerable to H1N1 infection.
Competitiondate
201001
Approvedterm2
1 yr 0 mth
Pinamesdelim
Knight, Darryl A
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $94,155~ $0~
