Grant: Canada Research Chairs
The University of British Columbia
$120,000.00
Single-Molecule Biophysics and Mechanobiology
FY 2024-25
Summary
Mechanical interactions among cells dictate biological processes from organism development to diseases such as cancer and neurodegeneration. Revealing the mechanisms behind these mechanical processes require force measurement and control at the molecular level. To address this open question, this CRC research program will develop new tools and methods to investigate how molecular forces regulate cell function in the immune and nervous systems. The program requires an interdisciplinary approach combining DNA nanotechnology, single-molecule biophysics and mechanobiology. Beyond advancing fundamental molecular and cellular research, disease-relevant mechanisms discovered under this program will have the potential to create new treatment
strategies.
Program
Canada Research Chairs
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
CRC-2020-00143
Name nom
Li, Isaac
Department département
Chemistry - The University of British Columbia
Organization id
2
Institution établissement
The University of British Columbia
Province en
British Columbia
Province fr
Colombie-Britannique
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2024
Competition year année de concours
2020
Award amount
120000
Program id
CRC
Program name en
Canada Research Chairs
Program name fr
Chaires de recherche du Canada
Group en
DISCOVERY RESEARCH
Group fr
RECHERCHE AXÉE SUR LA DÉCOUVERTE
Committee code
9998
Committee name en
Canada Research Chair Selection Committee
Committee name fr
Comité de sélection des Chaires de recherche du Canada
Area of application code
9999
Area of application group en
Not available
Area of application group fr
Non disponible
Area of application en
Not available
Area of application fr
Non disponible
Research subject code
9999
Research subject group en
Not available
Research subject group fr
Non disponible
Research subject en
Not available
Research subject fr
Non disponible
Field of research list codes
RDF10406; RDF20701
Field of research list names en
Physical chemistry (including structural);Medical and biomedical engineering
Field of research list names fr
Chimie physique (y compris la chimie structurale);Génie médical et biomédical
Socioeconomic objective list names en
Not available
Socioeconomic objective list names fr
Non disponible
Application title
Single-Molecule Biophysics and Mechanobiology
Keywords
biophysics; single-molecule method; mechanobiology; ; physical chemistry; modelling; DNA nanotechnology; force sensors; imaging; adhesion receptors; rolling adhesion; synaptic adhesion
Application summary
Mechanical interactions among cells dictate biological processes from organism development to diseases such as cancer and neurodegeneration. Revealing the mechanisms behind these mechanical processes require force measurement and control at the molecular level. To address this open question, this CRC research program will develop new tools and methods to investigate how molecular forces regulate cell function in the immune and nervous systems. The program requires an interdisciplinary approach combining DNA nanotechnology, single-molecule biophysics and mechanobiology. Beyond advancing fundamental molecular and cellular research, disease-relevant mechanisms discovered under this program will have the potential to create new treatment
strategies.
