Grant: Master's Award: Canada Graduate Scholarships

Chemotherapy has greatly improved cancer treatment efficacy and survival rates. However, it can also cause serious side effects that affect general health, quality of life, and adherence to treatment plans. One of the most common side effects is chemobrain, a type of brain fog that impacts memory, attention, and decision-making. These cognitive challenges can persist both short- and long-term, sometimes lasting for years after treatment, significantly influencing daily life and creating socioeconomic and healthcare burdens. Unfortunately, effective treatments for chemobrain are scarce. The hippocampus, a brain region vital for memory and attention, is particularly affected by chemotherapy. Previous studies have shown that structural and functional changes in hippocampal cells are linked to cognitive impairments caused by chemotherapy drugs. However, how chemotherapy alters the electrical activity of neurons in this region is still unclear. In this project, we aim to explore how chemotherapy drugs affect hippocampal neuron function and contribute to chemobrain. We will use a mouse model treated with the chemotherapy drug 5-fluorouracil (5FU), known to cause chemobrain, to investigate these changes. Additionally, we will test the potential of Spirulina, a marine algae supplement rich in vitamins and minerals, known for its neuroprotective, anti-inflammatory, and cancer-fighting properties, to treat chemobrain. We expect that 5FU will cause significant changes in hippocampal neuron activity, while Spirulina will likely prevent these adverse effects, offering a safe, effective method to reduce cognitive deficits. This research could lead to new strategies for treating or preventing chemobrain, improving the lives of cancer patients and survivors.