Grant: Project Grant
University of British Columbia
$895,050.00
CRF modulation of motivation, decision making and dopamine transmission
FY 2022-23
Summary
Depression is associated with numerous symptoms. Among these are deficits in motivation, that can make an individual feel unable to engage in pursuits that may lead to things they find rewarding. Multiple abnormalities in brain chemistry have been implicated in driving certain symptoms of depression, one of which is abnormal increases in a stress-related neurotransmitter, corticotropin releasing factor (CRF). Work in our laboratory suggests that excessive CRF may play a key role in driving motivational deficits similar to what is seen in individuals suffering from depression. This research program will systematically investigate where in the brain CRF may act to cause these deficits, the brain circuits it acts upon and some of the neurochemical mechanisms that drives this dysfunction.
Department
Program
Project Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
468405
Name
Floresco Stanley B
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Behavioural Sciences - A: Neurobiological Basis of Behavioural Processes
Projecttitle
CRF modulation of motivation, decision making and dopamine transmission
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$895,050
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Corticotropin Releasing Factor; Decision Making; Dopamine; Motivation; Stress
Abstract
Depression is associated with numerous symptoms. Among these are deficits in motivation, that can make an individual feel unable to engage in pursuits that may lead to things they find rewarding. Multiple abnormalities in brain chemistry have been implicated in driving certain symptoms of depression, one of which is abnormal increases in a stress-related neurotransmitter, corticotropin releasing factor (CRF). Work in our laboratory suggests that excessive CRF may play a key role in driving motivational deficits similar to what is seen in individuals suffering from depression. This research program will systematically investigate where in the brain CRF may act to cause these deficits, the brain circuits it acts upon and some of the neurochemical mechanisms that drives this dysfunction.
Competitiondate
202209
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Floresco, Stanley B
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $895,050~ $0~
