Grant: Project Grant
University of British Columbia
$1,239,300.00
Placenta mitochondrial dysfunction and preterm birth
FY 2017-18
Summary
Mitochondria, in addition to being the energy power house of the cells, are also involved in the synthesis or many important hormones. This includes progesterone which is made in the placenta mitochondria, and is required to maintain pregnancy. We think that sometimes, the placenta mitochondria are dysfunctional and that it may play a role in women delivering before the pregnancy reaches term. Being born preterm can lead to many health problems for the child and we know that the risk of preterm delivery is greatly increased for women living with HIV. This may be related to the virus but also the therapy used to treat HIV. We want to study placenta mitochondria from
both preterm and term births to both HIV+ and HIV- mothers, and investigate their characteristics. We also want to use cultured placental cells to determine what HIV drugs may be less detrimental to mitochondrial function. This research will help understand why some children are born preterm and why HIV drugs may increase the risk of preterm birth
Department
Program
Project Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
369956
Name
Côté Hélène
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Clinical Investigation - A: Reproduction, Maternal, Child and Youth Health
Projecttitle
Placenta mitochondrial dysfunction and preterm birth
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$1,239,300
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Antiretroviral Therapy; Damage Associated Molecular Pattern; Damp; Hiv; Mitochondria; Mitochondrial Dysfunction; Placenta; Preterm Birth; Sterile Inflammation
Abstract
Mitochondria, in addition to being the energy power house of the cells, are also involved in the synthesis or many important hormones. This includes progesterone which is made in the placenta mitochondria, and is required to maintain pregnancy. We think that sometimes, the placenta mitochondria are dysfunctional and that it may play a role in women delivering before the pregnancy reaches term. Being born preterm can lead to many health problems for the child and we know that the risk of preterm delivery is greatly increased for women living with HIV. This may be related to the virus but also the therapy used to treat HIV. We want to study placenta mitochondria from
both preterm and term births to both HIV+ and HIV- mothers, and investigate their characteristics. We also want to use cultured placental cells to determine what HIV drugs may be less detrimental to mitochondrial function. This research will help understand why some children are born preterm and why HIV drugs may increase the risk of preterm birth
Competitiondate
201709
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Côté, Hélène
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,239,300~ $0~
