Grant: Catalyst Grant: COEN Initiative

Perhaps the greatest challenge in Alzheimer's disease (AD) genetics research is to understand the functional consequences of identified mutations. Until now, researchers have identified 217 mutations in genes genetically associated with AD. However, no gene is clearly pinpointed as being a culprit, and additional strategies are required to narrow down the list of candidates. microRNAs are small endogenous molecules that function to regulate gene expression. Recently, we have identified a number of mutations in AD genes affecting microRNA function. We now aim to explore in detail the relationship between AD genetics data and microRNAs. We will use our unique expertise in genetics, molecular biology, as well as animal and human studies. Overall, we aim to uncover unprecedented roles of AD-associated mutations. This will help understand the cause(s) of AD, and open the door to novel biomarkers and therapeutic avenues.