Grant: Emerging Team Grant: Regenerative Medicine and Nanomedicine
University of Toronto
$2,335,000.00
Vascularized Tissue Engineered Constructs
FY 2010-11
Summary
One of the major challenges of replacing or regenerating tissues using tissue engineering is the ability to obtain a functional blood supply following implantation of the construct or cells into the body. This team submission is focused on the biology of regenerating blood vessels and specifically endothelial cells (EC), the cells which line the internal surfaces of all blood vessels, in the context of modular tissue engineering - a novel approach to tissue engineering. Studies will examine the influence of EC interactions with other cell types, as well as the effects of blood flow. The new knowledge obtained on EC function during remodelling will be used to design novel therapies with a view to achieving improved/accelerated vascularization.
Department
Program
Emerging Team Grant: Regenerative Medicine and Nanomedicine
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
209149
Name
Sefton Michael V
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Emerging Team Grant: Regenerative Medicine and Nanomedicine
Projecttitle
Vascularized Tissue Engineered Constructs
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$2,335,000
Cihrequipment2
$0
Programname2
Emerging Team Grant: Regenerative Medicine and Nanomedicine
Keyworddelim
Endothelial Cells; Gene Regulation; Hemodynamics; Host Response; Regenerative Medicine; Remodeling; Tissue Engineering; Vascularization
Abstract
One of the major challenges of replacing or regenerating tissues using tissue engineering is the ability to obtain a functional blood supply following implantation of the construct or cells into the body. This team submission is focused on the biology of regenerating blood vessels and specifically endothelial cells (EC), the cells which line the internal surfaces of all blood vessels, in the context of modular tissue engineering - a novel approach to tissue engineering. Studies will examine the influence of EC interactions with other cell types, as well as the effects of blood flow. The new knowledge obtained on EC function during remodelling will be used to design novel therapies with a view to achieving improved/accelerated vascularization.
Competitiondate
201007
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sefton, Michael V; Cybulsky, Myron I; Marsden, Philip A; Simmons, Craig A
Approvedterm
5 ans 0 mois
Cihrcontribution2
Inst of Circ &Respiratory Hlth~ $250,000~ $0~Pan - Institute init. (MISI)~ $2,085,000~ $0~
