Grant: Team Grant: Embracing Diversity to Achieve Precision & Health Equity-Aging - LOI

Venous thromboembolism (VTE) is a set of blood-clotting diseases that involve the vein system. An important cause of morbidity and mortality worldwide, VTE affects approximately 1 in 10 individuals during their lifetime. Risk of this condition is strongly associated with age, and recent data has identified clonal hematopoiesis of indeterminate potential (CHIP), a set of age-dependent, inflammation-driven genetic changes in the blood-forming system, as a novel predictor of VTE. Despite differences in VTE characteristics by race and ethnicity, racialized groups are poorly represented in clinical studies involving VTE, including its association with CHIP. Through a cross-disciplinary approach, we aim to gain further insight into the frequency and significance of CHIP among racialized older adults living with VTE. In so doing, we will support knowledge translation efforts to equitably reduce the burden of VTE at a population level.