Grant: Engage Grants for universities
Hallam, Steven (The University of British Columbia)
$25,000.00
Model directed phycocyanin over-production in blooming algal cell-factories
FY 2017-18 · 2018-03-07
Summary
Regulating the metabolic expression of photosynthetic microorganisms offers the possibility of producing_x000D_
high-value chemicals directly from sunlight, water and carbon dioxide. Despite a plethora of phenotypic and_x000D_
molecular information, only a few cyanobacterial isolates have been developed into tractable genetic systems_x000D_
with associated genome-scale metabolic models. This limits the number of strains that can be used as platform_x000D_
chemical producers. AlgaBloom International, a Vancouver-based biotech company specializing in bioreactor_x000D_
design and cynaobacterial cell growth, is interested in developing their specific strain of Spirulina, optimized_x000D_
for high growth yields, as a platform chemical producer to extend their market range and profitability. Through_x000D_
the application of genome-scale metabolic modeling techniques and controlled laboratory growth experiments,_x000D_
this project aims to redirect metabolite flow through desired biosynthetic pathways in Spirulina. During this_x000D_
phase of the project we will specifically focus on genome sequencing and model directed over-production of_x000D_
phycocyanin, a valuable photosynthetic pigment with multiple applications in the food, medical and_x000D_
instrumentation industries. Predicted overproduction phenotypes will be tested at both bench- and pilot-scales_x000D_
and an optimized phycocyanin extraction and purification protocol will be developed for AlgaBloom.
Program
Engage Grants for universities
Location
British Columbia|Colombie-Britannique, Canada
Recipient Type
Academia
Type
Grant
Source
Proactive Disclosure - Grants and Contributions
As published
Additional Information
Grant or Award spanning more than one fiscal year (2017-2018 to 2018-2019).
Additional Information (French)
Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier (2017-2018 à 2018-2019).
Agreement Number
EGP
Agreement Start Date
2018-03-07
Agreement Title
Model directed phycocyanin over-production in blooming algal cell-factories
Agreement Title (French)
Model directed phycocyanin over-production in blooming algal cell-factories
Agreement Type
Grant
Agreement Value
$25,000.00
Amendment Number
0
Organization Code
nserc-crsng
Organization
Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada
Program Name
Engage Grants for universities
Program Name (French)
Subventions d'engagement partenarial pour les universités
Program Purpose
Regulating the metabolic expression of photosynthetic microorganisms offers the possibility of producing_x000D_
high-value chemicals directly from sunlight, water and carbon dioxide. Despite a plethora of phenotypic and_x000D_
molecular information, only a few cyanobacterial isolates have been developed into tractable genetic systems_x000D_
with associated genome-scale metabolic models. This limits the number of strains that can be used as platform_x000D_
chemical producers. AlgaBloom International, a Vancouver-based biotech company specializing in bioreactor_x000D_
design and cynaobacterial cell growth, is interested in developing their specific strain of Spirulina, optimized_x000D_
for high growth yields, as a platform chemical producer to extend their market range and profitability. Through_x000D_
the application of genome-scale metabolic modeling techniques and controlled laboratory growth experiments,_x000D_
this project aims to redirect metabolite flow through desired biosynthetic pathways in Spirulina. During this_x000D_
phase of the project we will specifically focus on genome sequencing and model directed over-production of_x000D_
phycocyanin, a valuable photosynthetic pigment with multiple applications in the food, medical and_x000D_
instrumentation industries. Predicted overproduction phenotypes will be tested at both bench- and pilot-scales_x000D_
and an optimized phycocyanin extraction and purification protocol will be developed for AlgaBloom.
Program Purpose (French)
Regulating the metabolic expression of photosynthetic microorganisms offers the possibility of producing_x000D_
high-value chemicals directly from sunlight, water and carbon dioxide. Despite a plethora of phenotypic and_x000D_
molecular information, only a few cyanobacterial isolates have been developed into tractable genetic systems_x000D_
with associated genome-scale metabolic models. This limits the number of strains that can be used as platform_x000D_
chemical producers. AlgaBloom International, a Vancouver-based biotech company specializing in bioreactor_x000D_
design and cynaobacterial cell growth, is interested in developing their specific strain of Spirulina, optimized_x000D_
for high growth yields, as a platform chemical producer to extend their market range and profitability. Through_x000D_
the application of genome-scale metabolic modeling techniques and controlled laboratory growth experiments,_x000D_
this project aims to redirect metabolite flow through desired biosynthetic pathways in Spirulina. During this_x000D_
phase of the project we will specifically focus on genome sequencing and model directed over-production of_x000D_
phycocyanin, a valuable photosynthetic pigment with multiple applications in the food, medical and_x000D_
instrumentation industries. Predicted overproduction phenotypes will be tested at both bench- and pilot-scales_x000D_
and an optimized phycocyanin extraction and purification protocol will be developed for AlgaBloom.
Recipient City
British Columbia|Colombie-Britannique
Recipient Country
CA
Recipient Legal Name
Hallam, Steven (The University of British Columbia)
Reference Number
GC-2017-Q4-00733
