Grant: CIHR Fellowship
Direct Payment
$150,000.00
Developing Targeted Antibacterial Strategies to Alleviate Disease in the Human Microbiome
FY 2015-16
Summary
The human body has even more bacterial cells than it does human cells, and new research is helping us understand what these bacteria do. Recent studies have shown that some of these bacteria can make drug-like chemicals that can cause diseases like cancer, heart disease, and colitis. Unfortunately, traditional antibiotics will remove good bacteria as well as bad ones, and this can lead to infections by hardy microbes like C. difficile. In this research proposal, we suggest that new, engineered microbes could be used to remove only specific, targeted bacteria, leaving the rest unharmed. The approach we describe could be applied to any number of bad bacteria or even genes in the future, providing a means to address new discoveries as they become apparent, and prevent serious diseases caused by the bacteria that live inside us.
Department
Program
CIHR Fellowship
Recipient
Location
Massachusetts, United States of America
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
338812
Name
Johnston Chad W
Region
Massachusetts
Country
United States of America
Orgtype
Research Institution
Partnername
Canadian Association of Gastroenterology (Oakville, Ontario)
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Fellowships - Post-PhD
Projecttitle
Developing Targeted Antibacterial Strategies to Alleviate Disease in the Human Microbiome
Programtype2
Fellowship Programs
Orgnameinp2
Direct Payment
Cihramount2
$150,000
Cihrequipment2
$0
Programname2
CIHR Fellowship
Keyworddelim
Advanced Antibacterials; Human Microbiome; Synthetic Biology; Targeted Therapeutics
Abstract
The human body has even more bacterial cells than it does human cells, and new research is helping us understand what these bacteria do. Recent studies have shown that some of these bacteria can make drug-like chemicals that can cause diseases like cancer, heart disease, and colitis. Unfortunately, traditional antibiotics will remove good bacteria as well as bad ones, and this can lead to infections by hardy microbes like C. difficile. In this research proposal, we suggest that new, engineered microbes could be used to remove only specific, targeted bacteria, leaving the rest unharmed. The approach we describe could be applied to any number of bad bacteria or even genes in the future, providing a means to address new discoveries as they become apparent, and prevent serious diseases caused by the bacteria that live inside us.
Competitiondate
201511
Approvedterm2
3 yrs 0 mth
Pinamesdelim
Johnston, Chad W
Approvedterm
3 ans 0 mois
Cihrcontribution2
~ $150,000~ $0~
