Grant: Operating Grant
Université Laval
$497,439.00
Antioxidant effects of n3-polyunsaturated fatty acids in the vasculature.
FY 2011-12
Summary
Omega-3 fatty acids from marine origin are recognized for their beneficial effects in the prevention of cardiovascular diseases, the major cause of death in Canada. However, their mechanism of action is not fully understood. With the present application, we plan to determine if omega 3 acids can stimulate the production of a natural antioxidant, named bilirubin. By reducing the oxidation of blood lipids, bilirubin exerts beneficial effects in the vascular system. To reach our objectives, we will combine innovative and state-of-the-art approaches in molecular biology, molecular pharmacology and clinical studies.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
239962
Name
Barbier Olivier
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Pharmaceutical Sciences
Projecttitle
Antioxidant effects of n3-polyunsaturated fatty acids in the vasculature.
Programtype2
Operating Grants
Orgnameinp2
Université Laval
Cihramount2
$497,439
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Animal Models; Antioxydant; Cardiovascular Diseases; Clinical Study; Molecular Pharmacology; N3-Polyunsaturated Fatty Acids
Abstract
Omega-3 fatty acids from marine origin are recognized for their beneficial effects in the prevention of cardiovascular diseases, the major cause of death in Canada. However, their mechanism of action is not fully understood. With the present application, we plan to determine if omega 3 acids can stimulate the production of a natural antioxidant, named bilirubin. By reducing the oxidation of blood lipids, bilirubin exerts beneficial effects in the vascular system. To reach our objectives, we will combine innovative and state-of-the-art approaches in molecular biology, molecular pharmacology and clinical studies.
Competitiondate
201109
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Barbier, Olivier
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $497,439~ $0~
