Grant: Operating Grant

We have identified new brain regions which may play critical roles in the regulating food intake, metabolism and thus body weight. These structures known as the circumventricular organs are unique in that they are the only regions of the brain with the ability to sense multiple satiety signals including glucose, leptin, amylin and many other signaling molecules as they lack the blood brain barrier. Our proposal outlines studies which will describe the roles of two of these circumventricular organs in the integrated regulation of energy metabolism. These studies will potentially provide important new targets for the treatment of obesity and other metabolic diseases.