Grant: Operating Grant
Université de Montréal
$800,440.00
Analysis of the molecular mechanisms by which the MARCH1 E3-ubiquitin ligase regulates immune responses and tolerance.
FY 2013-14
Summary
Our main objective is to understand the mechanism by which the body can terminate immune reactions against invaders so
that chronic inflammation and autoimmune diseases do not ensue. IL-10 is a mediator that is secreted by immune cells and
circulates in blood to signal other cells to stop an immune reaction. This signal results in the production of a protein called
MARCH1, which tones down the immune reaction. We have a mouse that is genetically modified and does not express this
protein. We have shown that this mouse is highly susceptible to inflammation triggered by bacterial components. We
propose to study the structure and function of this protein in macrophages. These cells are important both for the initiation of
immune reaction and for healing. Thus, as a potential therapeutic avenue, we hope to be able to manipulate many pathways
involved in the activation or suppression of immune responses.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
303785
Name
Thibodeau Jacques
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Immunology & Transplantation
Projecttitle
Analysis of the molecular mechanisms by which the MARCH1 E3-ubiquitin ligase regulates immune responses and tolerance.
Programtype2
Operating Grants
Orgnameinp2
Université de Montréal
Cihramount2
$800,440
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Energy Metabolism; Flow Cytometry; Il-10; Immunology; Inflammation; Knock Out Mice; Lps; Macrophages; Mhc Class Ii; Ubiquitin Ligase
Abstract
Our main objective is to understand the mechanism by which the body can terminate immune reactions against invaders so
that chronic inflammation and autoimmune diseases do not ensue. IL-10 is a mediator that is secreted by immune cells and
circulates in blood to signal other cells to stop an immune reaction. This signal results in the production of a protein called
MARCH1, which tones down the immune reaction. We have a mouse that is genetically modified and does not express this
protein. We have shown that this mouse is highly susceptible to inflammation triggered by bacterial components. We
propose to study the structure and function of this protein in macrophages. These cells are important both for the initiation of
immune reaction and for healing. Thus, as a potential therapeutic avenue, we hope to be able to manipulate many pathways
involved in the activation or suppression of immune responses.
Competitiondate
201403
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Thibodeau, Jacques
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $800,440~ $0~
