Grant: Project Grant

Bipolar disorder is a serious mood disorder that is a leading cause of functional disability worldwide. Energy deficits are a core feature of bipolar disorder, and contribute to difficulties in daily functioning and reduced quality of life in people living with bipolar disorder. Problems with the functioning of mitochondria, also known as the powerhouse of the cell, may be driving the energy deficits in bipolar disorder. These tiny energy generators in our cells are significantly influenced by genetic factors. Our group has shown that greater genetic risk for reduced mitochondrial function is associated with reduced blood flow in key brain regions among youth with bipolar disorder. The current study seeks to advance knowledge regarding how mitochondrial genetics are related to blood flow in the brain, as well as energy and activity, among people with bipolar disorder across the lifespan. We will recruit 180 participants with bipolar disorder, ages 16 to 75, and 180 community controls. This landmark study will bring together novel genetic analyses with well-matched brain imaging measures. Energy will be measured with a wearable activity tracking device (Oura Ring) and self-reported questionnaires. Our overall goal is to make progress with the ongoing challenge of energy deficits in bipolar disorder. By combining genetics, brain imaging, and detailed clinical information, this line of research has the potential to yield knowledge that can ultimately benefit the lives of individuals with bipolar disorder for whom energy deficits pose an ongoing challenge.