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Grant: Project Grant

McMaster University

$765,000.00

Cannabis exposure in utero: impact on the developmental programming of the gut-brain axis

FY 2022-23

Summary
Up to one third of women believe that cannabis is safe to use in pregnancy, with women turning to cannabis for relief of pregnancy symptoms, such as morning sickness. One of the reasons why cannabis is thought to be helpful for morning sickness is that cannabis can act directly on the gut, and especially on the nerves that help the gut move and feel what is in it. We already know that early life is an important time for the formation of the nerves in the gut, and for the nerves that connect the gut to the brain. We also know that influences from the outside world, such as medications taken by the mother, and the way bacteria normally colonize babies, can change how these gut-brain connections work. Our expert team want to find out if a mother's use of cannabis can affect the gut of her baby and lead to problems with feeding, heartburn, abdominal discomfort, and constipation. Parenting people are asking for higher quality information so they can make informed decisions regarding timing and types of cannabis use.
Program
Project Grant
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database

As published

Id
479332
Name
Ratcliffe Elyanne M
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Human Development, Child and Youth Health
Theme2
Biomedical
Prcname2
Clinical Investigation - A: Reproduction, Maternal, Child and Youth Health
Projecttitle
Cannabis exposure in utero: impact on the developmental programming of the gut-brain axis
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$765,000
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Cannabis; Developmental Programming; Disorders Of Gut-Brain Interaction; Early Life; Endocannabinoid System; Enteric Nervous System; Gut-Brain Axis; In Utero; Microbiome; Pregnancy
Abstract
Up to one third of women believe that cannabis is safe to use in pregnancy, with women turning to cannabis for relief of pregnancy symptoms, such as morning sickness. One of the reasons why cannabis is thought to be helpful for morning sickness is that cannabis can act directly on the gut, and especially on the nerves that help the gut move and feel what is in it. We already know that early life is an important time for the formation of the nerves in the gut, and for the nerves that connect the gut to the brain. We also know that influences from the outside world, such as medications taken by the mother, and the way bacteria normally colonize babies, can change how these gut-brain connections work. Our expert team want to find out if a mother's use of cannabis can affect the gut of her baby and lead to problems with feeding, heartburn, abdominal discomfort, and constipation. Parenting people are asking for higher quality information so they can make informed decisions regarding timing and types of cannabis use.
Competitiondate
202303
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Ratcliffe, Elyanne M
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $765,000~ $0~