Grant: Operating Grant
University of Calgary
$978,301.00
Regulation of PNKP and XRCC4 in non-homologous end-joining by dynamic, reversible protein phosphorylation.
FY 2011-12
Summary
Ionizing radiation (IR) is used extensively in the treatment of many forms of cancer. It acts by inducing lethal DNA damage, in particular a form called a DNA double strand break or DSB. The major pathway for the repair of IR-induced DSBs in human cells is called non-homologous end-joining or NHEJ. We have identified IR-induced modifications of two of the key proteins in NHEJ: XRCC4 and PNKP. This grant explains how we will characterize these modifications to understand how they regulate how cells repair IR-induced DSBs. This work will help us to understand the basic processes by which cells detect and repair IR-induced DNA damage and could lead to better treatments for cancer patients.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
253967
Name
Lees-Miller Susan P
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Cancer Biology & Therapeutics
Projecttitle
Regulation of PNKP and XRCC4 in non-homologous end-joining by dynamic, reversible protein phosphorylation.
Programtype2
Operating Grants
Orgnameinp2
University of Calgary
Cihramount2
$978,301
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Atm; Dna Repair; Dna-Pk; Ionizing Radiation; Non-Homologous End-Joining; Pnkp; Protein Kinase; Protein Phosphatase; Protein Phosphorylation; Xrcc4
Abstract
Ionizing radiation (IR) is used extensively in the treatment of many forms of cancer. It acts by inducing lethal DNA damage, in particular a form called a DNA double strand break or DSB. The major pathway for the repair of IR-induced DSBs in human cells is called non-homologous end-joining or NHEJ. We have identified IR-induced modifications of two of the key proteins in NHEJ: XRCC4 and PNKP. This grant explains how we will characterize these modifications to understand how they regulate how cells repair IR-induced DSBs. This work will help us to understand the basic processes by which cells detect and repair IR-induced DNA damage and could lead to better treatments for cancer patients.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Lees-Miller, Susan P
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $978,301~ $0~
