Grant: Operating Grant
McGill University
$778,470.00
The role of ErbB2-14-3-3 sigma signaling axis in cancer and development
FY 2009-10
Summary
The development of breast cancer involves the coordinate loss of genes that negatively regulate the capacity epithelial cells to divide termed tumour suppressors and the elevated expression of other gene termed oncogenes that promote epithelial cell division. The major objective of this proposal is to investigate the role of 14-3-3 sigma tumour suppressor in breast cancer development. Using a well defined mouse model of human breast cancer, we hope to elucidate the molecular basis for the ability of this tumour suppressor to stop breast cancer cells from dividing.
Department
Program
Operating Grant
Recipient
Location
Quebec, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
199253
Name
Muller William J
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Genetics
Projecttitle
The role of ErbB2-14-3-3 sigma signaling axis in cancer and development
Programtype2
Operating Grants
Orgnameinp2
McGill University
Cihramount2
$778,470
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Cell Polarity; Erbb2; Metastasis; Tumour Suppressor
Abstract
The development of breast cancer involves the coordinate loss of genes that negatively regulate the capacity epithelial cells to divide termed tumour suppressors and the elevated expression of other gene termed oncogenes that promote epithelial cell division. The major objective of this proposal is to investigate the role of 14-3-3 sigma tumour suppressor in breast cancer development. Using a well defined mouse model of human breast cancer, we hope to elucidate the molecular basis for the ability of this tumour suppressor to stop breast cancer cells from dividing.
Competitiondate
201003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Muller, William J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $778,470~ $0~
