Grant: Alliance Grants
Brock University
$25,000.00
Exploring the effects of spaceflight on maternal programming and offspring skeletal muscle function
FY 2023-24
Summary
Use it or lose it - it is well known that spaceflight causes our muscles to shrink and weaken. However, whether these effects of spaceflight can be passed down to future generations remains unknown. In collaboration with NASA and Dr. Lane Christenson (University of Kansas Medical Centre), our research will explore whether the deleterious effects of spaceflight on muscle can be passed down. Female mice flown in SpaceX-CRS29 and housed in the International Space Station (ISS) for about a month were returned to Earth to breed and give birth to male and female pups. With help from Aurora Scientific (Ontario, Canada), a world-leader in the production and distribution of contractile equipment, we will test whether muscles from mice born from mums aboard the ISS are weaker than those from mice born from mums who remained on Earth. Our research is all part of a Canadian commitment to space research that will allow for travel to the moon and Mars.
Program
Alliance Grants
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
NSERC's Awards Data
As published
Application id
591061-2023
Name nom
Fajardo, Val Andrew VAM
Department département
Kinesiology
Organization id
22
Institution établissement
Brock University
Province en
Ontario
Province fr
Ontario
Country en
CANADA
Country fr
CANADA
Fiscal year exercice financier
2023
Competition year année de concours
2023
Award amount
25000
Program id
ALLRP
Program name en
Alliance Grants
Program name fr
Subventions Alliance
Group en
RESEARCH PARTNERSHIPS
Group fr
PARTENARIATS DE RECHERCHE
Committee code
96
Committee name en
RPP Internal Decision Cttee
Committee name fr
Cté de décision interne - PPR
Area of application code
1201
Area of application group en
Advancement of knowledge
Area of application group fr
Avancement des connaissances
Area of application en
Life sciences (including biotechnology)
Area of application fr
Sciences de la vie (y compris biotechnologie)
Research subject code
5502
Research subject group en
Animal biology
Research subject group fr
Kinesiology
Research subject en
Biologie animale
Research subject fr
Kinésiologie
Application title
Exploring the effects of spaceflight on maternal programming and offspring skeletal muscle function
Keyword
Calcium handling; Fatigue; GSK3; Maternal programming; Skeletal muscle strength; Spaceflight
Application summary
Use it or lose it - it is well known that spaceflight causes our muscles to shrink and weaken. However, whether these effects of spaceflight can be passed down to future generations remains unknown. In collaboration with NASA and Dr. Lane Christenson (University of Kansas Medical Centre), our research will explore whether the deleterious effects of spaceflight on muscle can be passed down. Female mice flown in SpaceX-CRS29 and housed in the International Space Station (ISS) for about a month were returned to Earth to breed and give birth to male and female pups. With help from Aurora Scientific (Ontario, Canada), a world-leader in the production and distribution of contractile equipment, we will test whether muscles from mice born from mums aboard the ISS are weaker than those from mice born from mums who remained on Earth. Our research is all part of a Canadian commitment to space research that will allow for travel to the moon and Mars.
