Grant: Operating Grant
Unity Health Toronto
$634,685.00
Molecular mechanisms generating and maintaining phospholipid asymmetry and its consequences.
FY 2013-14
Summary
Cholesterol is an essential molecule for human life. However, excess cholesterol is associated with a variety of pathologies most notably heart disease. The organization and distribution of cholesterol is influenced by a variety of protein as well as other fats. The distribution and organization of these fats are regulated by a variety of proteins, referred to as scramblases and flippases. Not surprisingly, mutations in these proteins are proposed to influence a myriad of disorders including male infertility, bile acid accumulation in the liver, diabetes, obesity and neurological defects. This proposal will explore both the cell biological roles of phosphatidylserine and the proteins that regulate its distribution and their impact on the distribution of cholesterol within the cell. Understanding the function of this lipid within the cell and the proteins that regulate it will help us understand the disorders described and aid in the development of treatments.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
291159
Name
Fairn Gregory D
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Cell Physiology
Projecttitle
Molecular mechanisms generating and maintaining phospholipid asymmetry and its consequences.
Programtype2
Operating Grants
Orgnameinp2
Unity Health Toronto
Cihramount2
$634,685
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Biochemistry; Caveolae; Cell Biology; Endocytosis; Fluorescence Microscopy; Golgi; Lipid-Signaling; Metabolism; Molecular Biology; Secretion
Abstract
Cholesterol is an essential molecule for human life. However, excess cholesterol is associated with a variety of pathologies most notably heart disease. The organization and distribution of cholesterol is influenced by a variety of protein as well as other fats. The distribution and organization of these fats are regulated by a variety of proteins, referred to as scramblases and flippases. Not surprisingly, mutations in these proteins are proposed to influence a myriad of disorders including male infertility, bile acid accumulation in the liver, diabetes, obesity and neurological defects. This proposal will explore both the cell biological roles of phosphatidylserine and the proteins that regulate its distribution and their impact on the distribution of cholesterol within the cell. Understanding the function of this lipid within the cell and the proteins that regulate it will help us understand the disorders described and aid in the development of treatments.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Fairn, Gregory D
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $634,685~ $0~
