Grant: Project Grant

Gamma-delta T cells act as a first line of defense against pathogens in barrier tissues such as the gut and lung. They act to directly combat bacteria and fungi, and also send out signals to additional cells to join the immune response. However, they can also contribute to autoimmune diseases and promote cancer progression. The ability of these cells to perform these functions is set up during their development from blood stem cells. In this proposal, we will define the molecular events that lead to the acquisition of the pro-inflammatory IL-17 program in gamma-delta T cells. We will focus on the roles of HEB transcription factors, which control gene expression, and on the extracellular signals that modulate their activity. A better understanding of how these cells are programmed for function during T cell development will enable us to target and modulate these important immune functions to promote health and combat disease.