Grant: Project Grant
McMaster University
$650,250.00
Characterization of an interkingdom-targeting protein secretion system in Gram-positive bacteria
FY 2019-20
Summary
Many of the bacteria that make us sick release harmful toxins that not only damage our own healthy cells but also kill the beneficial bacteria that live within us. Harmful bacteria such as Streptococcus release their toxins by using a "nanomachine" known as the type VII secretion system (T7SS). This proposal seeks to uncover how the T7SS nanomachine operates at the molecular level. This detailed information is needed before rational strategies to disable the T7SS can be developed. Disabling the T7SS nanomachine will prevent harmful bacteria from damaging healthy cells in humans while sparing the beneficial bacterial cells in our bodies that keep us healthy.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
418964
Name
Whitney John
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Infection and Immunity
Theme2
Biomedical
Prcname2
Biochemistry & Molecular Biology - A
Projecttitle
Characterization of an interkingdom-targeting protein secretion system in Gram-positive bacteria
Programtype2
Operating Grants
Orgnameinp2
McMaster University
Cihramount2
$650,250
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Bacterial Genetics; Biochemistry; Effector Proteins; Molecular Biology; Protein Export; Streptococcus; Structural Biology; Type Vii Secretion System
Abstract
Many of the bacteria that make us sick release harmful toxins that not only damage our own healthy cells but also kill the beneficial bacteria that live within us. Harmful bacteria such as Streptococcus release their toxins by using a "nanomachine" known as the type VII secretion system (T7SS). This proposal seeks to uncover how the T7SS nanomachine operates at the molecular level. This detailed information is needed before rational strategies to disable the T7SS can be developed. Disabling the T7SS nanomachine will prevent harmful bacteria from damaging healthy cells in humans while sparing the beneficial bacterial cells in our bodies that keep us healthy.
Competitiondate
202003
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Whitney, John
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $650,250~ $0~
