Grant: Operating Grant
York University (Toronto, Ontario)
$521,550.00
Mechanisms regulating metabolic effects of adiponectin in obesity and diabetes
FY 2013-14
Summary
It is well established that obesity is a major risk factor for diabetes. However, the precise mechanisms responsible for regulating changes in insulin sensitivity and energy metabolism remain to be fully determined. This project will focus on the role played by a substance (adiponectin) which is released from fat cells. Upon release, adiponectin can travel in the bloodstream to have effects in peripheral metabolic tissues such as skeletal muscle and liver. Interestingly, the amount of adiponectin circulating in the blood decreases in obese and diabetic individuals. We intend to determine how too little adiponectin alters insulin sensitivity and energy metabolism. Understanding this may facilitate development of new treatments to reduce morbidity and mortality in individuals with obesity and diabetes.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
290931
Name
Sweeney Gary
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Nutrition, Metabolism and Diabetes
Theme2
Biomedical
Prcname2
Diabetes, Obesity, Lipid & Lipoprotein Disorders
Projecttitle
Mechanisms regulating metabolic effects of adiponectin in obesity and diabetes
Programtype2
Operating Grants
Orgnameinp2
York University (Toronto, Ontario)
Cihramount2
$521,550
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Adiponectin; Cell Signalling; Diabetes; Endothelial Transport; Metabolism; Skeletal Muscle
Abstract
It is well established that obesity is a major risk factor for diabetes. However, the precise mechanisms responsible for regulating changes in insulin sensitivity and energy metabolism remain to be fully determined. This project will focus on the role played by a substance (adiponectin) which is released from fat cells. Upon release, adiponectin can travel in the bloodstream to have effects in peripheral metabolic tissues such as skeletal muscle and liver. Interestingly, the amount of adiponectin circulating in the blood decreases in obese and diabetic individuals. We intend to determine how too little adiponectin alters insulin sensitivity and energy metabolism. Understanding this may facilitate development of new treatments to reduce morbidity and mortality in individuals with obesity and diabetes.
Competitiondate
201309
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Sweeney, Gary
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $521,550~ $0~
