Grant: Project Grant
University of Manitoba
$642,180.00
miRacles for abnormal lung development in congenital diaphragmatic hernia; defining the role of miR-200b
FY 2015-16
Summary
Every day, 150 babies are born with a hole in the diaphragm and abnormal lung development, a disease known as congenital diaphragmatic hernia (CDH). We currently do not know why their lungs develop abnormally. It is important to investigate this, since 1/3 of these babies die from respiratory problems after birth. In our laboratory, we have identified a small piece of genetic code - a microRNA called miR-200b - that might play a very important role during the abnormal lung development in CDH babies. We will investigate how miR-200b regulates lung development and how disrupted miR-200b abundance leads to abnormal lung development in CDH. Our studies will help to better understand lung development in CDH and we will use this information to plan future therapies aimed at improving lung development in these babies before they are even born.
Department
Program
Project Grant
Recipient
Location
Manitoba, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
345019
Name
Keijzer Richard
Region
Manitoba
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Project Grant Competition
Projecttitle
miRacles for abnormal lung development in congenital diaphragmatic hernia; defining the role of miR-200b
Programtype2
Operating Grants
Orgnameinp2
University of Manitoba
Cihramount2
$642,180
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Congenital Diaphragmatic Hernia; Lung Development; Lung Hypoplasia; Micrornas; Mir-200b
Abstract
Every day, 150 babies are born with a hole in the diaphragm and abnormal lung development, a disease known as congenital diaphragmatic hernia (CDH). We currently do not know why their lungs develop abnormally. It is important to investigate this, since 1/3 of these babies die from respiratory problems after birth. In our laboratory, we have identified a small piece of genetic code - a microRNA called miR-200b - that might play a very important role during the abnormal lung development in CDH babies. We will investigate how miR-200b regulates lung development and how disrupted miR-200b abundance leads to abnormal lung development in CDH. Our studies will help to better understand lung development in CDH and we will use this information to plan future therapies aimed at improving lung development in these babies before they are even born.
Competitiondate
201603
Approvedterm2
4 yrs 0 mth
Pinamesdelim
Keijzer, Richard
Approvedterm
4 ans 0 mois
Cihrcontribution2
~ $642,180~ $0~
