Grant: Travel Awards - Institute Community Support
Memorial University of Newfoundland
$1,000.00
Copy number variations (CNVs) and colorectal cancer
FY 2015-16
Summary
Colorectal cancer is a common cancer affecting thousands of Canadians. Genetic factors contributing to the disease risk and outcome are not fully understood. Recently discovered genetic variations, which consist of variable numbers of deleted or duplicated DNA segments, are presumed to play roles in the development and progression of colorectal cancer.
In this study we used a largescale genetic data of 505 colorectal cancer patients. The genetic variations in DNA of each patient were identified by using genetic detection software. Additional analyses showed that some of these variations might affect genes' functions. A subgroup of the identified variations were also experimentally verified that increased our confidence in the results. Additionally, we are in the process of examining the relation of these variations with patient survival times.
This is one of the first comprehensive studies identified these genetic variations in colorectal cancer patients. Our results have generated new scientific knowledge. In addition, once our current analyses identify the genetic variations that are linked to patient survival times, the resulted information may be valuable in the clinical management of future colorectal cancer patients.
Department
Program
Travel Awards - Institute Community Support
Recipient
Location
Newfoundland and Labrador, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
331842
Name
Werdyani Salem
Region
Newfoundland and Labrador
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Cancer Research
Theme2
Biomedical
Prcname2
Institute of Cancer Research
Projecttitle
Copy number variations (CNVs) and colorectal cancer
Programtype2
Undefined
Orgnameinp2
Memorial University of Newfoundland
Cihramount2
$1,000
Cihrequipment2
$0
Programname2
Travel Awards - Institute Community Support
Keyworddelim
Bioinformatics; Colorectal Cancer; Computational Analysis; Copy Number Variations (Cnvs); Experimental Validation; Genetic Variations; Pathway Analysis; Patient Outcomes; Small Insertion And Deletions (Indels); Statistical Survival Analyses
Abstract
Colorectal cancer is a common cancer affecting thousands of Canadians. Genetic factors contributing to the disease risk and outcome are not fully understood. Recently discovered genetic variations, which consist of variable numbers of deleted or duplicated DNA segments, are presumed to play roles in the development and progression of colorectal cancer.
In this study we used a largescale genetic data of 505 colorectal cancer patients. The genetic variations in DNA of each patient were identified by using genetic detection software. Additional analyses showed that some of these variations might affect genes' functions. A subgroup of the identified variations were also experimentally verified that increased our confidence in the results. Additionally, we are in the process of examining the relation of these variations with patient survival times.
This is one of the first comprehensive studies identified these genetic variations in colorectal cancer patients. Our results have generated new scientific knowledge. In addition, once our current analyses identify the genetic variations that are linked to patient survival times, the resulted information may be valuable in the clinical management of future colorectal cancer patients.
Competitiondate
201505
Approvedterm2
1 yr 0 mth
Pinamesdelim
Werdyani, Salem
Approvedterm
1 an 0 mois
Cihrcontribution2
Inst of Cancer Research~ $1,000~ $0~
