Grant: Team Grant: Transforming Health and Care Systems Joint Transnational Call

PRIME (Post-tReatment preventIve MEdication for the transition for Breast Cancer in Oncology) is an international research initiative aiming to propose an integrated survivorship model to improve the care and the quality of life for women aged 65 and older undergoing long-term adjuvant endocrine therapy (AET) after breast cancer. This population often experiences persistent side effects, fragmented care, and insufficient support, leading to treatment discontinuation and reduced well-being. Despite partial solutions, no integrated, sustainable model has been widely adopted. PRIME brings together researchers, clinicians, patients, advocates, oncology experts, and health system stakeholders from five countries to co-design a novel empowerment-based integrated survivorship model that promotes self-management, encourage links between stakeholders, and improves the navigation of health and social systems. PRIME is structured around four core objectives: (1) mapping existing AET follow-up models and related policy contexts; (2) designing a patient empowerment intervention that includes a personalized educational pathway and peer support; (3) piloting the intervention in seven diverse healthcare settings; and (4) developing actionable recommendations for future implementation and research. With its cross-country comparative approach and strong focus on co-construction and patient engagement, PRIME aims to generate robust, transferable evidence on AET management for women aged 65 and older with breast cancer, and inform national and transnational policies in Europe, Switzerland, and Canada. By centering around the voices of women aged 65+, PRIME fosters equity, integration, and person-partnership in survivorship care, offering a solution to meet the needs for one of the fastest-growing patient populations in oncology.