Grant: Operating Grant
University of British Columbia
$562,020.00
Regulation of the Functional Distribution of Aquaporin 4 in Brain
FY 2009-10
Summary
Stroke is one of the leading causes of death in Canada. Mortality due to stroke is in large part due to abnormal water accumulation that leads to brain swelling and compression within the skull. Current treatment options to reduce the swelling of the brain, also called edema, due to stroke are limited, more than 70 years old and generally require surgical intervention. The limited development of new therapies attests of an incomplete understanding of the regulation of water accumulation in the brain. Thus, the major challenge in the development of new therapies is to better define the mechanism of water transport in brain. A key regulator of water transport in the brain is the water permeable channel, aquaporin 4, which is expressed in non-neuronal cells called glial cells. It is the goal of the present proposal to identify molecules that modulate aquaporin 4 function in glial cells and test whether they may prove to be useful in reducing water accumulation in models of brain edema.
Department
Program
Operating Grant
Recipient
Location
British Columbia, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
190802
Name
Moukhles Hakima
Region
British Columbia
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Cell Biology & Mechanisms of Disease
Projecttitle
Regulation of the Functional Distribution of Aquaporin 4 in Brain
Programtype2
Operating Grants
Orgnameinp2
University of British Columbia
Cihramount2
$562,020
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Aquaporin 4-Mediated Water Transport; Astrocytes; Brain Edema; Confocal And Electron Microscopy; Dystroglycan Interaction With The Extracellular Matrix; Fluorescence; Protein-Protein Interactions
Abstract
Stroke is one of the leading causes of death in Canada. Mortality due to stroke is in large part due to abnormal water accumulation that leads to brain swelling and compression within the skull. Current treatment options to reduce the swelling of the brain, also called edema, due to stroke are limited, more than 70 years old and generally require surgical intervention. The limited development of new therapies attests of an incomplete understanding of the regulation of water accumulation in the brain. Thus, the major challenge in the development of new therapies is to better define the mechanism of water transport in brain. A key regulator of water transport in the brain is the water permeable channel, aquaporin 4, which is expressed in non-neuronal cells called glial cells. It is the goal of the present proposal to identify molecules that modulate aquaporin 4 function in glial cells and test whether they may prove to be useful in reducing water accumulation in models of brain edema.
Competitiondate
200909
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Moukhles, Hakima
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $562,020~ $0~
