Grant: Project Grant

People with bipolar disorder spend as much as half their lives suffering from depression. Medications for bipolar disorder more often address the manic phase of the illness, and more research is needed into medications for bipolar depression. A drug called candesartan is already used in Canada to treat high blood pressure and heart failure. Research suggests that candesartan may have mood benefits. Candesartan may also be helpful in treating bipolar depression. Because people with bipolar disorder face a greater risk of heart and blood vessel issues, candesartan may also provide an additional benefit by reducing these issues. Candesartan is already widely available in Canada, inexpensive, and safe for use as directed by a physician for high blood pressure and heart failure. In this study, we will assess its effectiveness and safety among patients with bipolar disorder who are experiencing depression. Patients will be assigned to one of two groups: the experimental group that will receive candesartan and the control group that will receive a placebo. Researchers will meet with patients to carry out standardized psychological interviews that assess their mental health. The team will also collect blood samples from participants at set periods of time to ensure the drug is safe for use.