Grant: Project Grant
University of Toronto
$734,400.00
Metabolic regulation of mitochondrial proteostasis
FY 2017-18
Summary
Mitochondria, as the powerhouses of the cell, undergo damage. These damaged mitochondria have to be selectively removed from the cell, and replaced with healthy ones, otherwise the cell dies causing human neurodegenerative disease. We have identified a novel pathway that regulates this process. By a combination of cell biology and biochemistry, we will characterize a detailed molecular pathway, that may allow for the design of therapeutics to combat human neurodegenerative diseases like Parkinson's disease.
Department
Program
Project Grant
Recipient
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
370682
Name
Mcquibban George A
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Cell Physiology
Projecttitle
Metabolic regulation of mitochondrial proteostasis
Programtype2
Operating Grants
Orgnameinp2
University of Toronto
Cihramount2
$734,400
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Mitochondrial Biology; Mitophagy; Neurodegenerative Disease; Parkinson'S Disease
Abstract
Mitochondria, as the powerhouses of the cell, undergo damage. These damaged mitochondria have to be selectively removed from the cell, and replaced with healthy ones, otherwise the cell dies causing human neurodegenerative disease. We have identified a novel pathway that regulates this process. By a combination of cell biology and biochemistry, we will characterize a detailed molecular pathway, that may allow for the design of therapeutics to combat human neurodegenerative diseases like Parkinson's disease.
Competitiondate
201709
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Mcquibban, George A
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $734,400~ $0~
