Grant: Catalyst Grant: Analysis of CLSA Data

In Canada, as in the rest of the world, poor physical function increases after 50 years of age, with a peak at age 65. Poor physical function is a key determinant of poor physical and mental health, greater risk of institutionalization, and mortality. Poor physical function appears earlier and at greater frequency in women than in men. Current research suggests that experiencing menopause earlier in life and having surgically-induced menopause (removal of the ovaries before menopause), rather than natural menopause, is related to lower physical function. Our objective is to assess the relationship between age at menopause, and type of menopause (surgically-induced vs. natural) on physical function in older women (65-74 years) in Canada and globally. In addition, we aim to investigate the role of physical activity, hormone therapy, cardiovascular disease, social support, and resilience on the relationship between menopause and physical function. We will use baseline data from the Canadian Longitudinal Study on Aging Comprehensive cohort (CLSA, 7 cities across Canada) and the International Mobility in Aging Study (IMIAS, 5 cities around the world). By analyzing these different cohorts of women, we will be able to identify risks related to poor physical function in women with a broad range of experiences across the life course, as well as different social norms and expectations. With an aging population and an overburden to health systems around the world, targeting physical function and looking for determinants that can reduce loss of function in women at older ages, we will offer new avenues for more effective ways of intervention. In this regard, we expect our results could further inform research and clinical actions exploring the benefits of physical activity, hormone therapy, and early intervention that targets better social opportunities for women before menopause.