Grant: Operating Grant
University of Alberta
$669,700.00
PrP N-terminal sequences and biological endpoints in Prion and Alzheimer's Disease
FY 2011-12
Summary
Prion diseases such as mad cow are caused by a normal component of brain cells, the cellular prion protein, "PrPC", folding into the wrong 3D shape. Interestingly we and others have described that PrPC participates in early chemical events in a different disease, Alzheimer's, that also features cell-to-cell spread of a misfolded protein. In this work we have found that PrPC exists in three forms and that one form is especially relevant to how prion diseases occur and may also play a special role in the early events of Alzheimer's. We will explore these concepts using petri dish and animal model experiments.
Department
Program
Operating Grant
Recipient
Location
Alberta, Canada
Recipient Type
Academia
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
255928
Name
Westaway David
Region
Alberta
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Neurosciences, Mental Health and Addiction
Theme2
Biomedical
Prcname2
Cell Biology & Mechanisms of Disease
Projecttitle
PrP N-terminal sequences and biological endpoints in Prion and Alzheimer's Disease
Programtype2
Operating Grants
Orgnameinp2
University of Alberta
Cihramount2
$669,700
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Alzheimer'S; Cell-To-Cell Spread; Dementia; Infecitivity; Ion Channels; Metalloproteins; Prions; Protein Folding; Transgenics; Transition Metals
Abstract
Prion diseases such as mad cow are caused by a normal component of brain cells, the cellular prion protein, "PrPC", folding into the wrong 3D shape. Interestingly we and others have described that PrPC participates in early chemical events in a different disease, Alzheimer's, that also features cell-to-cell spread of a misfolded protein. In this work we have found that PrPC exists in three forms and that one form is especially relevant to how prion diseases occur and may also play a special role in the early events of Alzheimer's. We will explore these concepts using petri dish and animal model experiments.
Competitiondate
201203
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Westaway, David
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $669,700~ $0~
