Grant: Operating Grant
Ottawa Hospital Research Institute
$1,016,040.00
Genetic manipulation of the mouse SirT1 locus to investigate cancer susceptibility, response to calorie restriction, and fertility.
FY 2008-09
Summary
The lifespan of a species is a characteristic determined by the genetic composition of the organism. Genes of the sir2 family are known to modulate the lifespan of simple organisms. We are studying a member of this gene family in mammals and plan to modify this gene in mice to test the idea that the gene determines the response of animals to the onset of diseases such as cancer that terminate life. This application describes a variety of gene modifications that will allow us to modulate its activity and hence determine whether ablation or activation has effects on the animals' health.
Department
Program
Operating Grant
Recipient
Location
Ontario, Canada
Recipient Type
Other
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
180150
Name
McBurney Michael W
Region
Ontario
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Aging
Theme2
Biomedical
Prcname2
Biological and Clinical Aspects of Aging
Projecttitle
Genetic manipulation of the mouse SirT1 locus to investigate cancer susceptibility, response to calorie restriction, and fertility.
Programtype2
Operating Grants
Orgnameinp2
Ottawa Hospital Research Institute
Cihramount2
$1,016,040
Cihrequipment2
$0
Programname2
Operating Grant
Keyworddelim
Calorie Restriction; Embryonic Stem Cells; Fertility; Homologous Recombination; Mouse Genetics
Abstract
The lifespan of a species is a characteristic determined by the genetic composition of the organism. Genes of the sir2 family are known to modulate the lifespan of simple organisms. We are studying a member of this gene family in mammals and plan to modify this gene in mice to test the idea that the gene determines the response of animals to the onset of diseases such as cancer that terminate life. This application describes a variety of gene modifications that will allow us to modulate its activity and hence determine whether ablation or activation has effects on the animals' health.
Competitiondate
200903
Approvedterm2
5 yrs 0 mth
Pinamesdelim
McBurney, Michael W
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,016,040~ $0~
