Grant: Foundation Grant

Sexually transmitted infections (STI) are a major public health concern among Canadians. Human papillomavirus (HPV) is the most common STI, so much so that ¾ people will get this infection at least once. This is concerning because certain HPV types cause cervical, anal, and oral cancers. Rates of chlamydia, gonorrhea, and syphilis have risen for more than a decade. HIV infections continue and the effects of STIs are worse among people living with HIV. STIs are more commonly diagnosed among gay men with HIV than the general population. Women and men with HIV are many times more likely to get a cancer caused by HPV compared to people without HIV. Our vision is to gather the highest quality evidence to help Canadians choose the best vaccination & screening strategies to prevent and control STIs and STI-related cancers among Canadians at risk, especially those living with HIV. The newest HPV vaccines could prevent 90% of cancers caused by these viruses and are effective and safe, including in people with HIV. The negative consequences of STIs can be largely avoided by testing more often and getting treated right away. This not only improves patient health but prevents passing on the infection to partners. Screening for early signs of cancers caused by HPV, such as Pap tests for women, can ensure proper follow-up to prevent cancer development. Solutions will specifically address communities that may be harder to reach due to stigma and poverty. First, we will find out why people do or do not get vaccinated or tested for STIs and cancers caused by HPV. Next we will test new ways to offer vaccination & screening to see which are most effective and practical. Finally, we will follow our progress over the long term to ensure that chosen strategies protect the health of Canadians for years to come. Globally, 1 million people acquire an STI each day. Thus lessons learned may also assist international efforts to end STI epidemics, complications & deaths.