Grant: Project Grant
Research Institute of the McGill University Health Centre
$1,055,700.00
The role of trained macrophages in dystrophic diaphragm pathology
FY 2024-25
Summary
Duchenne muscular dystrophy (DMD), the most common genetic muscle disease, is lethal with no cure at this point in time. Most patients succumb to respiratory failure, which is caused by gradual destruction of the diaphragm, the main breathing muscle. The muscle pathology in DMD is characterized by chronic inflammation with a prominent invasion by immune cells known as macrophages. Previous studies performed by our lab demonstrate that these macrophages become overly active even before they reach the muscle, and this hyperactivity is linked to changes in how their genes are regulated. By studying these changes, we aim to find new ways to protect the diaphragm from damage, which could lead to better treatments for people with DMD and other similar muscle diseases.
Department
Program
Project Grant
Location
Quebec, Canada
Type
Grant
Source
CIHR Funding Decisions Database
As published
Id
509025
Name
Petrof Basil J
Region
Québec
Country
Canada
Orgtype
Institution Paid; Research Institution
Instname2
Circulatory and Respiratory Health
Theme2
Biomedical
Prcname2
Respiratory System
Projecttitle
The role of trained macrophages in dystrophic diaphragm pathology
Programtype2
Operating Grants
Orgnameinp2
Research Institute of the McGill University Health Centre
Cihramount2
$1,055,700
Cihrequipment2
$0
Programname2
Project Grant
Keyworddelim
Chemokines; Diaphragm; Epigenetics; Innate Immunity; Macrophages; Muscle Contractility; Muscle Fibrosis; Muscular Dystrophy; Respiratory Failure; Trained Immunity
Abstract
Duchenne muscular dystrophy (DMD), the most common genetic muscle disease, is lethal with no cure at this point in time. Most patients succumb to respiratory failure, which is caused by gradual destruction of the diaphragm, the main breathing muscle. The muscle pathology in DMD is characterized by chronic inflammation with a prominent invasion by immune cells known as macrophages. Previous studies performed by our lab demonstrate that these macrophages become overly active even before they reach the muscle, and this hyperactivity is linked to changes in how their genes are regulated. By studying these changes, we aim to find new ways to protect the diaphragm from damage, which could lead to better treatments for people with DMD and other similar muscle diseases.
Competitiondate
202409
Approvedterm2
5 yrs 0 mth
Pinamesdelim
Petrof, Basil J
Approvedterm
5 ans 0 mois
Cihrcontribution2
~ $1,055,700~ $0~
