Grant: Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
University of Waterloo|Université de Waterloo
$350,000.00
High Frame Rate Ultrasound Monitoring of Cerebral Blood Flow in Astronauts
FY 2021-22 · 2022-03-17
Summary
Spaceflights pose risk on the cerebrovascular health of astronauts because humans are not accustomed to living under microgravity conditions. To facilitate cerebrovascular health assessments, it is essential to monitor cerebral blood flow accurately.
This project will seek to advance the state-of-art in monitoring cerebral blood flow in astronauts (and humans on Earth) by designing a new non-invasive diagnostic tool that can robustly measure the volume flow rate through the internal carotid artery that supplies circulation to the brain. These space physiology investigations and engineering innovations will be crucial for understanding the cerebrovascular health risks of human spaceflights, especially for long-term space missions to Mars that require multiple years of space travel.
Our research investigations will also directly benefit cerebrovascular health monitoring on Earth, particularly in facilitating early detection of cerebral hypoperfusion. As the elderly population is especially at risk of experiencing cerebral perfusion problems, the outcomes of this project will serve well to address diagnostic needs in promoting health aging of the elderly (and the overall Canadian population). In addition, the proposed technology will be relevant for use in remote, resource-limited communities in rural Canada. Moreover, from a talent development perspective, this project will foster several trainees to develop multidisciplinary expertise at the frontiers of space physiology and ultrasound technology. In turn, it will help Canada build an outstanding talent pool for medical device innovations.
Department
Program
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Location
Waterloo|Waterloo, Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
Proactive Disclosure - Grants and Contributions
Amendments
Each version of the agreement as published, oldest first, with its total as of that version. The amount above is the latest.
| Amendment | Date | Fiscal Year | Total |
|---|---|---|---|
| 0 | 2022-03-17 | 2021-22 | $300,000.00 |
| 1 | 2022-03-17 | 2021-22 | $350,000.00 |
As published
Additional Information
The Proponent has requested to increase the grant amount by $50,000 to cover the National Research Council’s (NRC) fees for required Project flight hours due to a change in the NRC Flight Research Laboratory’s payment policy and to extend the Project completion date to August 31, 2026, in order to complete project activities.
Additional Information (French)
Le bénéficiaire a demandé d’augmenter le montant de la subvention de 50 000 $ afin de couvrir les frais du Conseil national de recherches (CNRC) pour les heures de vol requises du projet, en raison d’un changement dans la politique de paiement du laboratoire de recherche en vol du CNRC, et de prolonger la date d’achèvement du projet jusqu’au 31 août 2026 afin de terminer les activités du projet.
Agreement End Date
2026-08-31
Agreement Number
21FAWATA08
Agreement Start Date
2022-03-17
Agreement Title
High Frame Rate Ultrasound Monitoring of Cerebral Blood Flow in Astronauts
Agreement Title (French)
Surveillance par ultrasons à haut débit du débit sanguin cérébral chez les astronautes
Agreement Type
Grant
Agreement Value
$350,000.00
Amendment Date
2025-10-02
Amendment Number
1
Description
Spaceflights pose risk on the cerebrovascular health of astronauts because humans are not accustomed to living under microgravity conditions. To facilitate cerebrovascular health assessments, it is essential to monitor cerebral blood flow accurately.
This project will seek to advance the state-of-art in monitoring cerebral blood flow in astronauts (and humans on Earth) by designing a new non-invasive diagnostic tool that can robustly measure the volume flow rate through the internal carotid artery that supplies circulation to the brain. These space physiology investigations and engineering innovations will be crucial for understanding the cerebrovascular health risks of human spaceflights, especially for long-term space missions to Mars that require multiple years of space travel.
Our research investigations will also directly benefit cerebrovascular health monitoring on Earth, particularly in facilitating early detection of cerebral hypoperfusion. As the elderly population is especially at risk of experiencing cerebral perfusion problems, the outcomes of this project will serve well to address diagnostic needs in promoting health aging of the elderly (and the overall Canadian population). In addition, the proposed technology will be relevant for use in remote, resource-limited communities in rural Canada. Moreover, from a talent development perspective, this project will foster several trainees to develop multidisciplinary expertise at the frontiers of space physiology and ultrasound technology. In turn, it will help Canada build an outstanding talent pool for medical device innovations.
Description (French)
Les vols spatiaux posent un risque relativement à la santé cérébrovasculaire des astronautes, car les humains n’ont pas l’habitude de vivre dans des conditions de microgravité. Pour faciliter les évaluations de la santé cérébrovasculaire, il est essentiel de surveiller avec précision le débit sanguin cérébral.
Ce projet cherchera à faire progresser l’état des connaissances en matière de surveillance du débit sanguin cérébral chez les astronautes (et les humains sur Terre) en concevant un nouvel outil de diagnostic non invasif capable de mesurer rigoureusement le débit volumétrique à travers l’artère carotide interne qui alimente le cerveau. Ces recherches sur la physiologie spatiale et ces innovations techniques seront cruciales pour comprendre les risques des vols spatiaux habités pour la santé cérébrovasculaire, surtout lors des missions spatiales à long terme vers Mars qui nécessitent plusieurs années de voyage dans l’espace.
Nos recherches seront également directement bénéfiques pour la surveillance de la santé cérébrovasculaire sur Terre, en facilitant notamment la détection précoce de l’hypoperfusion cérébrale. Comme la population âgée est particulièrement à risque d’éprouver des problèmes de perfusion cérébrale, les résultats de ce projet serviront à combler les besoins diagnostiques dans le cadre de la promotion du vieillissement en santé des personnes âgées (et de l’ensemble de la population canadienne). De plus, l’utilisation de la technologie proposée s’avérera pertinente dans les collectivités éloignées aux ressources limitées du Canada rural. En outre, du point de vue du perfectionnement des talents, ce projet permettra à plusieurs stagiaires d’acquérir une expertise multidisciplinaire aux frontières de la physiologie spatiale et de la technologie des ultrasons. Conséquemment, cela aidera le Canada à constituer un bassin de talents exceptionnel favorisant l’innovation en matière de dispositifs médicaux.
Expected Results
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Expected Results (French)
Le volet Recherche du programme offre aux organisations une aide financière qui leur permettra de mener leurs activités de recherche et développement spatiales dans des secteurs prioritaires. Ce volet appuiera le développement des connaissances et l’innovation dans les domaines ciblés de manière à soutenir et à accroître la capacité du Canada d’utiliser l’espace pour répondre aux besoins et aux priorités du pays dans le futur.
Organization Code
csa-asc
Organization
Canadian Space Agency | Agence spatiale canadienne
Program Name
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Name (French)
Programme global de subventions et contributions à l'appui de la recherche, de la sensibilisation et de l'éducation en sciences et technologies spatiales
Program Purpose
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.
Program Purpose (French)
Ce programme appuie le développement des connaissances et l'innovation dans des domaines prioritaires de l'ASC et accroît la sensibilisation et la participation des Canadiens aux disciplines et aux activités liées à l'espace.
Le volet Recherche vise à soutenir le développement des sciences et des technologies, à favoriser le développement continu d'une masse critique de chercheurs et de personnes hautement qualifiées au Canada, et à appuyer la collecte d'information, la recherche et les études relatives à l'espace en tenant compte des priorités de l'ASC.
Recipient City
Waterloo|Waterloo
Recipient Country
CA
Recipient Legal Name
University of Waterloo|Université de Waterloo
Recipient Postal Code
N2L 3G1
Recipient Province or Territory
ON
Recipient Type
S
Reference Number
003-2021-2022-Q4-00048