Grant: Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Brock University|Brock University
$150,000.00
Inhibiting GSK3 to Preserve Musculoskeletal and Cognitive Health during Spaceflight
FY 2021-22 · 2022-03-29
Summary
Canada has committed efforts to push humanity further into the solar system beyond the International Space Station to more distant destinations like the Moon and Mars. However, travelling with the astronauts on these longer-duration missions are risks for muscle loss and weakness, bone fragility and cognitive decline, all of which will compromise astronaut well-being and the mission at hand. This research seeks to determine whether stopping an enzyme called glycogen synthase kinase 3 can slow the functional decline of muscles, bone, and brain not only in space but also here on Earth, providing novel therapeutic strategies for human health.
Department
Program
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Recipient
Location
St. Catharines|St. Catharines, Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
Proactive Disclosure - Grants and Contributions
Amendments
Each version of the agreement as published, oldest first, with its total as of that version. The amount above is the latest.
| Amendment | Date | Fiscal Year | Total |
|---|---|---|---|
| 0 | 2022-03-29 | 2021-22 | $150,000.00 |
| 1 | 2022-03-29 | 2021-22 | $150,000.00 |
| 2 | 2022-03-29 | 2021-22 | $150,000.00 |
As published
Agreement End Date
2025-07-01
Agreement Number
21HLSRM01
Agreement Start Date
2022-03-29
Agreement Title
Inhibiting GSK3 to Preserve Musculoskeletal and Cognitive Health during Spaceflight
Agreement Title (French)
Inhibition de GSK3 pour préserver la santé musculo-squelettique et cognitive pendant les vols spatiaux
Agreement Type
Grant
Agreement Value
$150,000.00
Amendment Date
2025-07-30
Amendment Number
2
Description
Canada has committed efforts to push humanity further into the solar system beyond the International Space Station to more distant destinations like the Moon and Mars. However, travelling with the astronauts on these longer-duration missions are risks for muscle loss and weakness, bone fragility and cognitive decline, all of which will compromise astronaut well-being and the mission at hand. This research seeks to determine whether stopping an enzyme called glycogen synthase kinase 3 can slow the functional decline of muscles, bone, and brain not only in space but also here on Earth, providing novel therapeutic strategies for human health.
Description (French)
Le Canada s'est engagé à pousser l'humanité plus loin dans le système solaire au-delà de la Station spatiale internationale pour
des destinations plus lointaines comme la Lune et Mars. Cependant, les vols habités de longue durée comportent des risques de santé tels que la perte et faiblesse musculaires, la fragilité osseuse et le déclin cognitif, qui compromettent le bien-être des astronautes et la mission à accomplir. Cette recherche vise à déterminer si l'arrêt d'une enzyme appelée la glycogène synthase kinase 3 peut ralentir le déclin fonctionnel des muscles, des os et du cerveau non seulement dans l'espace mais aussi ici sur Terre, offrant de nouvelles stratégies thérapeutiques pour la santé humaine.
Expected Results
The Research component of the program provides financial support to organizations to conduct space related research and development in priority areas. It will support targeted knowledge development and innovation to sustain and enhance the Canadian capacity to use space to address national needs and priorities in the future.
Expected Results (French)
Le volet Recherche du programme offre aux organisations une aide financière qui leur permettra de mener leurs activités de recherche et développement spatiales dans des secteurs prioritaires. Ce volet appuiera le développement des connaissances et l’innovation dans les domaines ciblés de manière à soutenir et à accroître la capacité du Canada d’utiliser l’espace pour répondre aux besoins et aux priorités du pays dans le futur.
Organization Code
csa-asc
Organization
Canadian Space Agency | Agence spatiale canadienne
Program Name
Class Grant and Contribution Program to Support Research, Awareness and Learning in Space Science and Technology
Program Name (French)
Programme global de subventions et contributions à l'appui de la recherche, de la sensibilisation et de l'éducation en sciences et technologies spatiales
Program Purpose
This program supports knowledge development and innovation in the CSA's priority areas while increasing the awareness and participation of Canadians in space-related disciplines and activities.
The Research Component aims to support the development of science and technology; foster the continual development of a critical mass of researchers and highly qualified people in Canada; and support information gathering and space-related studies and research pertaining to Canadian Space Agency priorities.
Program Purpose (French)
Ce programme appuie le développement des connaissances et l'innovation dans des domaines prioritaires de l'ASC et accroît la sensibilisation et la participation des Canadiens aux disciplines et aux activités liées à l'espace.
Le volet Recherche vise à soutenir le développement des sciences et des technologies, à favoriser le développement continu d'une masse critique de chercheurs et de personnes hautement qualifiées au Canada, et à appuyer la collecte d'information, la recherche et les études relatives à l'espace en tenant compte des priorités de l'ASC.
Recipient City
St. Catharines|St. Catharines
Recipient Country
CA
Recipient Legal Name
Brock University|Brock University
Recipient Postal Code
L2S 3A1
Recipient Province or Territory
ON
Recipient Type
S
Reference Number
003-2021-2022-Q4-00064