Contribution: Industrial Research Assistance Program – Contributions to Firms
Eurofins CDMO Alphora Inc.
$499,520.00
UK Biomanufacturing - 10136110 - NextGen ADC Platform-Engineering High-Yielding Expression Vectors and Peptide Linker Tags for Advanced ADC Production
FY 2025-26 · 2025-04-01
Summary
“As part of the international consortium project “NextGen ADC Platform: Engineering High-Yielding Expression Vectors and Peptide Linker Tags for Advanced ADC Production”, this project will aim to develop a novel expression platform for high-level production of monoclonal antibodies (mAbs) with optimized affinity peptide tags for development of advanced antibody drug conjugates (ADCs). This innovative approach eliminates the need for extra conjugation and purification steps, reducing the complexity and cost of ADC production and ultimately produces ADCs that can be reconstituted in the clinic, thereby simplifying the production processes.
The project brings together the expertise from Daresbury Proteins Ltd ("Daresbury"), a United Kingdom-based company specializing in novel expression platforms, the NRC and Eurofins CDMO Alphora Inc. ("Alphora").
Department
Program
Industrial Research Assistance Program – Contributions to FirmsIndustrial Research Assistance Program-Contributions to Firms (linked with high confidence)
Recipient
Location
Mississauga|Mississauga, Ontario, Canada
Recipient Type
For-profit organization
Business Number
879299600
Type
Contribution
Source
Proactive Disclosure - Grants and Contributions
As published
Agreement End Date
2027-03-30
Agreement Number
1030116
Agreement Start Date
2025-04-01
Agreement Title
UK Biomanufacturing - 10136110 - NextGen ADC Platform-Engineering High-Yielding Expression Vectors and Peptide Linker Tags for Advanced ADC Production
Agreement Title (French)
Biomanufacturing au Royaume-Uni - 10136110 - Plateforme ADC de nouvelle génération - Ingénierie de vecteurs d’expression à haut rendement et de marqueurs de liaison peptidique pour la production avancée d’ADC
Agreement Type
Contribution
Agreement Value
$499,520.00
Amendment Number
0
Coverage
IRAP Contributions to Firms projects stimulate wealth creation for Canada through technological innovation. | Les projets des Contributions aux entreprises stimulent la création de richesse au Canada grâce à l’innovation technologique.
Description
“As part of the international consortium project “NextGen ADC Platform: Engineering High-Yielding Expression Vectors and Peptide Linker Tags for Advanced ADC Production”, this project will aim to develop a novel expression platform for high-level production of monoclonal antibodies (mAbs) with optimized affinity peptide tags for development of advanced antibody drug conjugates (ADCs). This innovative approach eliminates the need for extra conjugation and purification steps, reducing the complexity and cost of ADC production and ultimately produces ADCs that can be reconstituted in the clinic, thereby simplifying the production processes.
The project brings together the expertise from Daresbury Proteins Ltd ("Daresbury"), a United Kingdom-based company specializing in novel expression platforms, the NRC and Eurofins CDMO Alphora Inc. ("Alphora").
Description (French)
Dans le cadre du projet international « NextGen ADC Platform : ingénierie de vecteurs d’expression à haut rendement et de marqueurs peptidiques pour la production avancée d’ADC », ce projet vise à développer une nouvelle plateforme d’expression pour la production à haut niveau d’anticorps monoclonaux (mAbs) avec des marqueurs peptidiques à affinité optimisée pour le développement de conjugués anticorps-médicaments (ADC) avancés. Cette approche innovante élimine le besoin d’étapes supplémentaires de conjugaison et de purification, réduisant ainsi la complexité et le coût de la production d’ADC et permettant finalement de produire des ADC qui peuvent être reconstitués en clinique, ce qui simplifie les processus de production. Le projet rassemble l’expertise de Daresbury Proteins Ltd (Daresbury), une société britannique spécialisée dans les nouvelles plateformes d’expression, du CNRC et d’Eurofins CDMO Alphora Inc. (Alphora).
Expected Results
The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization
Expected Results (French)
Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation
Federal Riding
Mississauga--Lakeshore
Federal Riding (French)
Mississauga--Lakeshore
Federal Riding Number
35061
NAICS Code
54171
Organization Code
nrc-cnrc
Organization
National Research Council Canada | Conseil national de recherches Canada
Program Name
Industrial Research Assistance Program – Contributions to Firms
Program Name (French)
Programme d’aide à la recherche industrielle – Contributions aux entreprises
Program Purpose
The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization
Program Purpose (French)
Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation
Recipient Business Number
879299600
Recipient City
Mississauga|Mississauga
Recipient Country
CA
Recipient Legal Name
Eurofins CDMO Alphora Inc.
Recipient Operating Name
Eurofins CDMO Alphora Inc.
Recipient Postal Code
L5K 1A9
Recipient Province or Territory
ON
Recipient Type
F
Reference Number
172-2025-2026-Q1-1030116
