Contribution: Industrial Research Assistance Program – Contributions to Firms
Pancella Inc.
$400,000.00
panKiller: Implementing a dual safety switch (suicide genes) in human pluripotent stem cells
FY 2019-20 · 2020-01-01
Summary
panKiller is an extension of panCELLa's proprietary FailSafe. panKiller is covered by the same patent as FailSafe: TOOLS AND METHODS FOR USING CELL DIVISION LOCI TO CONTROL PROLIFERATION OF CELLS. The patent was filed globally in most industrialized nations. panKiller involves the integration of a two-step safety switch. The first step utilizes FailSafe while the next step will utilize a second safety switch, panKiller, in order to eliminate all the therapeutic cells once therapy is complete and the therapeutic cells are no longer required. panKiller will link a suicide gene (iCaspase9) to a gene essential for cell survival (EEF2) in human induced pluripotent stem cells. There are currently no two-step safety switches on the market.
Department
Program
Industrial Research Assistance Program – Contributions to FirmsIndustrial Research Assistance Program-Contributions to Firms (linked with high confidence)
Recipient
Location
Toronto|Toronto, Ontario, Canada
Recipient Type
For-profit organization
Business Number
808132328
Type
Contribution
Source
Proactive Disclosure - Grants and Contributions
As published
Agreement End Date
2022-01-31
Agreement Number
947179
Agreement Start Date
2020-01-01
Agreement Title
panKiller: Implementing a dual safety switch (suicide genes) in human pluripotent stem cells
Agreement Title (French)
panKiller : mettre en place un double interrupteur de sécurité (gènes suicide) dans les cellules souches pluripotentes induites par l'humain
Agreement Type
Contribution
Agreement Value
$400,000.00
Amendment Number
0
Coverage
IRAP Contributions to Firms projects stimulate wealth creation for Canada through technological innovation. | Les projets des Contributions aux entreprises stimulent la création de richesse au Canada grâce à l’innovation technologique.
Description
panKiller is an extension of panCELLa's proprietary FailSafe. panKiller is covered by the same patent as FailSafe: TOOLS AND METHODS FOR USING CELL DIVISION LOCI TO CONTROL PROLIFERATION OF CELLS. The patent was filed globally in most industrialized nations. panKiller involves the integration of a two-step safety switch. The first step utilizes FailSafe while the next step will utilize a second safety switch, panKiller, in order to eliminate all the therapeutic cells once therapy is complete and the therapeutic cells are no longer required. panKiller will link a suicide gene (iCaspase9) to a gene essential for cell survival (EEF2) in human induced pluripotent stem cells. There are currently no two-step safety switches on the market.
Description (French)
panKiller est une extension de FailSafe, propriété de panCELLa. panKiller est couvert par le même brevet que FailSafe : OUTILS ET MÉTHODES D'UTILISATION DES LOCI DE DIVISION CELLULAIRE POUR CONTRÔLER LA PROLIFÉRATION DES CELLULES. Le brevet a été déposé au niveau mondial dans la plupart des pays industrialisés. panKiller comporte l'intégration d'un interrupteur de sécurité en deux étapes. La première étape utilise FailSafe tandis que la prochaine étape utilisera un second interrupteur de sécurité, le panKiller, afin d'éliminer toutes les cellules thérapeutiques une fois la thérapie terminée et que les cellules thérapeutiques ne sont plus nécessaires. Le panKiller reliera un gène suicide (iCaspase9) à un gène essentiel pour la survie des cellules (EEF2) dans les cellules souches pluripotentes induites par l'humain. Il n'existe actuellement sur le marché aucun interrupteur de sécurité en deux étapes.
Expected Results
The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization
Expected Results (French)
Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation
Federal Riding
University--Rosedale
Federal Riding (French)
University--Rosedale
Federal Riding Number
35110
NAICS Code
3254
Organization Code
nrc-cnrc
Organization
National Research Council Canada | Conseil national de recherches Canada
Program Name
Industrial Research Assistance Program – Contributions to Firms
Program Name (French)
Programme d’aide à la recherche industrielle – Contributions aux entreprises
Program Purpose
The purpose of IRAP Contributions to Firms is to support research, development, adoption and/or adaptation of innovative or technology-driven new or improved products, services or processes in Canada up to their commercialization
Program Purpose (French)
Le PARI, par le biais des Contributions aux entreprises, vise à appuyer la recherche, le développement, l’adaptation et/ou l’adoption au Canada de produits, de services ou de processus novateurs ou axés sur des technologies nouvelles ou améliorées, et ce jusqu’à leur commercialisation
Recipient Business Number
808132328
Recipient City
Toronto|Toronto
Recipient Country
CA
Recipient Legal Name
Pancella Inc.
Recipient Postal Code
M5G 0B7
Recipient Province or Territory
ON
Recipient Type
F
Reference Number
172-2019-2020-Q4-947179
