Grant: Collaborative Health Research Projects
Sinton, David (University of Toronto)
$272,390.00
Sperm Olympics: Selecting 1 in 100,000 for Intracytoplasmic Sperm Injection
FY 2017-18 · 2017-04-25
Summary
In North America, one in six couples experiences infertility - a 2-fold increase since 1992._x000D_
Assisted reproductive technologies (ARTs), such as in vitro fertilization (IVF) and_x000D_
intracytoplasmic sperm injection (ICSI), require human intervention to manually select sperm_x000D_
in the case of ICSI a single sperm. This manual process is expensive, inefficient, prone to_x000D_
operator-error and largely random, resulting in sub-optimal pregnancy outcomes and_x000D_
ultimately the health of offspring. No sperm selection method addresses this growing market_x000D_
and medical need. In 2015 we discovered a distinct swimming mode that human sperm use to_x000D_
navigate confined viscous regions of the female reproductive tract. We have formed a team of_x000D_
male fertility, microfluidic engineering, and clinical experts to develop and clinically test a_x000D_
microfluidic platform that leverages this natural swimming ability to select the highest quality_x000D_
sperm cells for direct injection - the Sperm Olympics.
Program
Collaborative Health Research Projects
Location
Ontario, Canada
Recipient Type
Academia
Type
Grant
Source
Proactive Disclosure - Grants and Contributions
As published
Additional Information
Grant or Award spanning more than one fiscal year. (2017-2018 to 2020-2021)
Additional Information (French)
Subvention ou bourse octroyée s'appliquant à plus d'un exercice financier. (2017-2018 à 2020-2021)
Agreement Number
CHRPJ
Agreement Start Date
2017-04-25
Agreement Title
Sperm Olympics: Selecting 1 in 100,000 for Intracytoplasmic Sperm Injection
Agreement Title (French)
Sperm Olympics: Selecting 1 in 100,000 for Intracytoplasmic Sperm Injection
Agreement Type
Grant
Agreement Value
$272,390.00
Amendment Number
0
Organization Code
nserc-crsng
Organization
Natural Sciences and Engineering Research Council of Canada | Conseil de recherches en sciences naturelles et en génie du Canada
Program Name
Collaborative Health Research Projects
Program Name (French)
Projets de recherche concertée sur la santé
Program Purpose
In North America, one in six couples experiences infertility - a 2-fold increase since 1992._x000D_
Assisted reproductive technologies (ARTs), such as in vitro fertilization (IVF) and_x000D_
intracytoplasmic sperm injection (ICSI), require human intervention to manually select sperm_x000D_
in the case of ICSI a single sperm. This manual process is expensive, inefficient, prone to_x000D_
operator-error and largely random, resulting in sub-optimal pregnancy outcomes and_x000D_
ultimately the health of offspring. No sperm selection method addresses this growing market_x000D_
and medical need. In 2015 we discovered a distinct swimming mode that human sperm use to_x000D_
navigate confined viscous regions of the female reproductive tract. We have formed a team of_x000D_
male fertility, microfluidic engineering, and clinical experts to develop and clinically test a_x000D_
microfluidic platform that leverages this natural swimming ability to select the highest quality_x000D_
sperm cells for direct injection - the Sperm Olympics.
Program Purpose (French)
In North America, one in six couples experiences infertility - a 2-fold increase since 1992._x000D_
Assisted reproductive technologies (ARTs), such as in vitro fertilization (IVF) and_x000D_
intracytoplasmic sperm injection (ICSI), require human intervention to manually select sperm_x000D_
in the case of ICSI a single sperm. This manual process is expensive, inefficient, prone to_x000D_
operator-error and largely random, resulting in sub-optimal pregnancy outcomes and_x000D_
ultimately the health of offspring. No sperm selection method addresses this growing market_x000D_
and medical need. In 2015 we discovered a distinct swimming mode that human sperm use to_x000D_
navigate confined viscous regions of the female reproductive tract. We have formed a team of_x000D_
male fertility, microfluidic engineering, and clinical experts to develop and clinically test a_x000D_
microfluidic platform that leverages this natural swimming ability to select the highest quality_x000D_
sperm cells for direct injection - the Sperm Olympics.
Recipient City
Ontario
Recipient Country
CA
Recipient Legal Name
Sinton, David (University of Toronto)
Reference Number
GC-2017-Q1-00246
