Grant: Operating Grant

Our research aims at elucidating the mechanism that regulates the survival, proliferation, and differentiation of sperm-producing stem cells, using the mouse as a model species. Spermatogenesis is the process to generate the male gamete, sperm, and continues for a lifetime after puberty. Sperm-producing stem cells are the foundation of this process. Our ability to understand the biology of these stem cells is crucial for preserving male fertility, producing healthy sperm, and maintaining the health of our children. For example, although the survival rate of cancer patients has significantly increased, anti-cancer treatments often cause infertility. This is particularly a serious problem for childhood cancer patients, because freeze-storing sperm is not an option for them to have their own children, due to their developmental immaturity. Therefore, encouraging the survival and function of stem cells during and after anti-cancer treatments will provide these patients with a great hope to establish their family in the post-cancer life. Our research will significantly contribute to realizing such a therapeutic strategy and to improving the quality of life of cancer survivors.